Investigating the link between heart tissue changes after a heart attack and dangerous heart rhythms.
Official title: LONGITUDINAL ASSOCIATION OF POST-INFARCT LIPOMATOUS METAPLASIA AND MALIGNANT ARRHYTHMIA
Funded at University of Pennsylvania · NIH-10981906 · Data updated 2026-11-12
This study is looking at how fat buildup in the heart after a heart attack can affect heart rhythms, and it's for patients who have had a heart attack to help understand their heart health better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $772,624 |
| NIH project number | 1R01HL171709-01A1 |
| Project ID | NIH-10981906 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a myocardial infarction and are at risk for developing arrhythmias.
✕Less likely to help
Patients who have not had a heart attack or do not have any history of cardiac issues may not benefit from this research.
What this research studies
This research focuses on understanding how changes in heart tissue, specifically fat deposition, occur after a heart attack and how these changes may lead to dangerous heart rhythms. By examining patients who have experienced a myocardial infarction, the study aims to identify the relationship between lipomatous metaplasia and the risk of malignant arrhythmias. The approach includes advanced cardiac imaging and electrophysiological assessments to track these changes over time. Patients will be monitored for heart function and rhythm disturbances, providing valuable insights into their condition.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing life-threatening heart rhythms in patients who have suffered a heart attack.
How similar studies have gone: Previous studies have shown promising results in understanding the relationship between heart tissue changes and arrhythmias, suggesting that this research builds on established findings.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Nazarian, Saman — University of Pennsylvania
- Study coordinator: Nazarian, Saman
Related research
Other NIH-funded projects on the same topics.
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Understanding how heart nerves affect dangerous heart rhythms after a heart attack
This NIH grant studies how changes in the heart’s nerve signaling after a heart attack lead to dangerous rhythm problems, with the goal of finding ways to prevent them.
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Dexterous needle ablation for ventricular arrhythmia guided by MRI
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Sex-specific heart cell signaling and rhythm problems linked to a heart failure drug target
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Additive-made wearable magnetic sensors for heart monitoring with AI
A wearable system using affordable, 3D-printed sensors and machine learning to help detect heart rhythm problems in people.
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Understanding fat deposits after heart attack and their link to dangerous heart rhythms
A Penn Medicine team is studying how fat buildup in the heart after a heart attack may influence dangerous heart rhythms and recovery.
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Developing 3D Real-Time CMR for Arrhythmia Imaging
Aims to make real-time 3D heart MRI usable for people with irregular heartbeats to improve how doctors see arrhythmias.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.