Investigating how genetics can help predict arrhythmia risk
Official title: Using Electrocardiogram Genetics to Inform Arrhythmia Risk
Funded at Massachusetts General Hospital · NIH-11010773 · Data updated 2026-11-12
This study is looking at how our genes might play a role in heart rhythm problems and sudden cardiac death, so we can better understand who might be at risk and help keep people safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 20, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $647,983 |
| NIH project number | 5R01HL157635-04 |
| Project ID | NIH-11010773 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of arrhythmias or sudden cardiac death, as well as those who have experienced unexplained cardiac events.
✕Less likely to help
Patients without any history of cardiac issues or genetic predisposition to arrhythmias may not benefit from this research.
What this research studies
This research aims to understand the genetic factors that contribute to arrhythmias and sudden cardiac death, which affect a significant portion of the population. By utilizing high-depth genomic sequencing data from large biobanks alongside electrocardiogram measurements, the study seeks to identify genetic variations that increase the risk of these conditions. The approach involves analyzing a vast repository of genomic and clinical data to uncover the underlying genetic causes of arrhythmias. This could lead to better risk assessment and management strategies for individuals at risk.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and preventing arrhythmias and sudden cardiac death in patients.
How similar studies have gone: Previous research has shown promise in using genetic data to inform cardiovascular risk, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Ellinor, Patrick Thomas — Massachusetts General Hospital
- Study coordinator: Ellinor, Patrick Thomas
Related research
Other NIH-funded projects on the same topics.
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Understanding fat deposits after heart attack and their link to dangerous heart rhythms
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Developing 3D Real-Time CMR for Arrhythmia Imaging
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.