Non-selective large conductance ion channels and triggered arrhythmia in hearts
Official title: Non-selective Large Conductance Ion Channels In Triggered Arrhythmia
Funded at Vanderbilt University Medical Center · NIH-11308283 · Data updated 2026-11-12
A study at Vanderbilt seeks to understand how certain ion channels in heart cells may trigger dangerous heart rhythms, with the goal of improving prevention and treatment for people at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $535,427 |
| NIH project number | 5R01HL164820-03 |
| Project ID | NIH-11308283 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with or at risk for ventricular arrhythmias or CPVT related mechanisms who could contribute samples or participate in studies that examine heart tissue or cellular models.
✕Less likely to help
Patients without arrhythmia risk or without related cardiac conditions may not directly benefit from this basic mechanistic study.
What this research studies
This project focuses on how random bursts of calcium release in heart cells can lead to abnormal heartbeats and potentially deadly arrhythmias. By examining non-selective large-conductance ion channels and their role in diastolic calcium release, the research aims to map how these channels contribute to triggered activity in human heart tissue. The team will use human-relevant models and detailed 3D structural information to connect cellular events to tissue-level behavior, with the hope of identifying targets for safer therapies. If successful, results could inform future interventions to reduce sudden cardiac death risk in patients with arrhythmia prone conditions.
Why it matters
Potential benefit: Findings could guide new strategies to prevent dangerous arrhythmias and reduce risk of sudden cardiac death in patients with heart conditions.
How similar studies have gone: Previous work has linked calcium handling and abnormal channel activity to triggered arrhythmias, but the specific role of non-selective large-conductance channels in intact tissue remains an area of active investigation.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Kryshtal, Dmytro O. — Vanderbilt University Medical Center
- Study coordinator: Kryshtal, Dmytro O.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.