Promoting daily steps to prevent osteoarthritis after ACL reconstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between daily step counts and knee joint cartilage health in individuals who have undergone anterior cruciate ligament reconstruction (ACLR). It aims to determine how low daily step frequency affects cartilage composition and resilience, potentially contributing to the development of osteoarthritis. Participants will be monitored for their daily steps using an Actigraph Link monitor, and comprehensive MRI assessments will be conducted to evaluate knee joint health. The study seeks to identify modifiable factors that could help prevent osteoarthritis in this at-risk population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Provision of signed and dated informed consent form
* For children, signed and dated informed assent by child and parental permission form by parent/guardian to participate in the study
* Underwent an anterior cruciate ligament reconstruction (ACLR) between 6-60 months prior to enrollment
* Stated willingness to comply with all study procedures and lifestyle considerations and availability for the duration of the study
* Completed all other formal physical therapy and therapeutic exercise regimens, and will not be engaging in any other formal therapy for their ACLR during the study
* Physician clearance for unrestricted activity
* Owning a smartphone
* Demonstrate \< 8,000 steps per day during the screening phase of aim 2 as assessed using the Actigraph Link monitor

Exclusion Criteria:

* Underwent an ACLR revision surgery due to a previous anterior cruciate ligament (ACL) graft injury
* A multiple ligament surgery was indicated with their ACL injury
* A lower extremity fracture was suffered during the ACL injury
* The participant has previously been diagnosed with any diseases that affect joints is present in either knee including knee osteoarthritis inflammatory arthritis
* Pregnant or plans to become pregnant over next 4 months
* Body mass index (BMI) ≥ 36 kg/m2
* Unable to speak English
* Cochlear implant
* Metal in body (metal fragments, shrapnel, permanent make-up, body piercings that cannot be removed)
* Claustrophobia
* History of seizures
* Pacemaker

Where it's running

• University of Georgia
  Athens, Georgia, United States Recruiting

Study contacts

• Principal investigator: Caroline Lisee, PhD — University of Georgia
• Study coordinator: Caroline Lisee, PhD
• Email: caroline.lisee@uga.edu
• Phone: 706-542-7137

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Perturbation Training vs Functional Activities after ACL Reconstruction

  This study tests whether perturbation training or task-oriented functional activities help people 18–45 with ACL reconstruction recover better than standard rehab.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07642752

• Tracking recovery after arthroscopic shoulder and knee surgeries

  This will follow people having routine arthroscopic shoulder or knee surgery to see if patient characteristics, tear details, or surgical choices predict better recovery and function over two years.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07501013

• Magic Angle Direction Imaging for ACL tears and meniscus injuries

  This study tries a new low-field MRI technique called Magic Angle Direction Imaging to see if it shows ACL tears and meniscus injuries more clearly in adults scheduled for ligament repair.

  Recruiting at 2 sites Imperial College London · London and 1 other locations · NCT07366619

• Proprioceptive exercises to aid recovery after ACL surgery

  This trial will see if adding proprioceptive exercises to standard balance training helps people aged 20–40 during the early rehab period after ACL surgery.

  Recruiting Uskudar University · Sanliurfa · NCT07333092

• Visual-guided balance training to improve knee function after ACL reconstruction

  This program tests whether adding visual-guided balance training to standard rehabilitation helps adults 18–45 recover knee function and walking after ACL reconstruction.

  Recruiting Peking University Third Hospital · Beijing · NCT07306221

• Predicting knee cartilage wear and pain after early osteoarthritis or a recent ACL injury

  This project will try to create computer models that predict cartilage damage and pain over time for people with early knee osteoarthritis or an ACL injury within the past year.

  Recruiting at 2 sites Aalborg University · Aalborg, North Denmark and 1 other locations · NCT07134244

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.