Comparing ACL repair and reconstruction for knee injuries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of arthroscopic anterior cruciate ligament (ACL) repair compared to the traditional ACL reconstruction in patients with acute ACL injuries. The study aims to determine if the repair technique, which preserves natural ligaments and reduces complications, is as effective as reconstruction. It involves a multicenter, randomized design with patients undergoing surgery within three weeks of their injury. The trial will provide high-quality evidence to guide treatment decisions for ACL injuries.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with anterior cruciate ligament tear clearly identified by imaging or intraoperative microscope, Sherman grade I, II; planned surgery within 3 weeks after injury
2. Basic reading and writing skills, and barrier-free communication
3. A smartphone, can use WeChat or be able to learn
4. Patients give informed consent, and sign the informed consent form, and the process must meet the requirements of GCP

Exclusion Criteria:

1. Combined with other knee joint injuries (posterior cruciate ligament injury, patellar dislocation, osteoarthritis, etc.)
2. Suffering from systemic immune diseases;
3. Existing other knee joint diseases or inflammatory diseases, including osteoarthritis, cervical spine disease, rheumatoid arthritis, fibromyalgia, polymyalgia rheumatica, etc.
4. Patients who have received local hormone injection within 3 months;
5. Those who have participated in clinical trials or are undergoing other clinical trials within 3 months before screening
6. Those who have serious primary cardiovascular disease, lung disease, endocrine and metabolic disease or serious diseases that affect their survival, such as tumor or AIDS, the researchers believe that they are not suitable for selection
7. Patients with severe liver disease, kidney disease, and hematological disease, such as renal function exceeding the upper limit of the normal value, and liver function exceeding 2 times the upper limit of the normal value;
8. Suffering from viral hepatitis, infectious diseases, severe abnormal blood coagulation mechanism and other Diseases that the researchers consider inappropriate for surgery
9. Women who are pregnant or breastfeeding, or who plan to become pregnant during the follow-up period, those who have a positive urine human chorionic gonadotropin test result before sampling; menstruating women should wait until the end of menstruation before surgery;
10. Severe neurological and mental disorders Disease patients;
11. Suspected or actual history of alcohol and drug abuse.

Where it's running

• Second Affiliated Hospital, School of Medicine, Zhejiang University
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Xuesong Dai, Doctor
• Email: daixshz@163.com
• Phone: +8613777882818

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Perturbation Training vs Functional Activities after ACL Reconstruction

  This study tests whether perturbation training or task-oriented functional activities help people 18–45 with ACL reconstruction recover better than standard rehab.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07642752

• Tracking recovery after arthroscopic shoulder and knee surgeries

  This will follow people having routine arthroscopic shoulder or knee surgery to see if patient characteristics, tear details, or surgical choices predict better recovery and function over two years.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07501013

• Magic Angle Direction Imaging for ACL tears and meniscus injuries

  This study tries a new low-field MRI technique called Magic Angle Direction Imaging to see if it shows ACL tears and meniscus injuries more clearly in adults scheduled for ligament repair.

  Recruiting at 2 sites Imperial College London · London and 1 other locations · NCT07366619

• Proprioceptive exercises to aid recovery after ACL surgery

  This trial will see if adding proprioceptive exercises to standard balance training helps people aged 20–40 during the early rehab period after ACL surgery.

  Recruiting Uskudar University · Sanliurfa · NCT07333092

• Visual-guided balance training to improve knee function after ACL reconstruction

  This program tests whether adding visual-guided balance training to standard rehabilitation helps adults 18–45 recover knee function and walking after ACL reconstruction.

  Recruiting Peking University Third Hospital · Beijing · NCT07306221

• Predicting knee cartilage wear and pain after early osteoarthritis or a recent ACL injury

  This project will try to create computer models that predict cartilage damage and pain over time for people with early knee osteoarthritis or an ACL injury within the past year.

  Recruiting at 2 sites Aalborg University · Aalborg, North Denmark and 1 other locations · NCT07134244

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.