Condition

ACL Injury clinical trials and research

• 20Clinical trials
• 8NIH research projects
• 9Countries

Newest ACL Injury clinical trials

All recruiting trials (20)

• Motor imagery–enhanced rehab after ACL reconstruction

  This study tests whether mentally practicing movement can improve knee function and brain activity after ACL reconstruction, in comparison with standard rehab.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality · NCT07833189

• Functional Movement Training vs Functional Stability Training after ACL Surgery

  This randomized trial tests whether a functional movement program or a stability-focused program helps 18-35 year old athletes recover after ACL surgery.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07725016

• Intraoperative Energy Use During ACL Surgery

  This study tests how much workload a surgeon experiences during ACL reconstruction procedures while wearing a Hexoskin shirt.

  Recruiting ASL Lecce · Lecce · NCT07683247

• Differences in Outcomes After Allograft vs Autograft in Revision ACL Repair

  This study looks at whether using donor tissue (allograft) versus the patient’s own tissue (autograft) in revision ACL surgery leads to different results.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Bologna · NCT07671235

• Functional brain signal changes after ACL reconstruction with targeted neuromotor training

  This project will test whether targeted neuromotor training after ACL reconstruction changes brain activity patterns in active adults aged 18–30.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Bologna · NCT07097077

• Assessing ACL injury risk in healthy athletes

  This study is trying to see how muscle strength and movement patterns in healthy athletes can help predict the risk of ACL injuries over a year.

  Recruiting Sanford Health · Fargo, North Dakota · NCT06635668

• Split-belt treadmill training to improve knee biomechanics after ACL reconstruction

  This small pilot will test whether six weeks of split-belt treadmill training can change how your reconstructed knee is loaded when you walk.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06529692

• Using PRP treatment after ACL reconstruction to improve recovery

  This study is testing if using platelet-rich plasma (PRP) after ACL surgery can help people heal better and lower their chances of developing arthritis.

  Recruiting Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz · Torun · NCT06442319

• Using concentrated bone marrow to improve outcomes in knee surgery

  This study is testing if using concentrated bone marrow during knee surgery can help people recover better and feel less pain after having their ACL surgery redone.

  Recruiting at 2 sites Phase 4 Hospital for Special Surgery, New York · Atlanta, Georgia and 1 other locations · NCT06311513

• Assessing soleus muscle strength in patients with ACL tears

  This study is testing the strength of a muscle in the calf of people with ACL tears to see how it compares to their uninjured leg and to healthy volunteers.

  Recruiting University of Liverpool · Liverpool · NCT06235736

• Cognitive dual-task training for athletes recovering from ACL surgery

  This study tests if adding brain exercises to physical therapy helps athletes recover better after ACL surgery and reduces the chance of getting hurt again.

  Recruiting University Ghent · Roeselare, West-Vlaanderen · NCT06206200

• Evaluating ACL injury and re-rupture rates after surgery

  This study looks at how often people who had ACL surgery from 2020 to 2030 experience re-injury and how their recovery affects their ability to return to sports and quality of life.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan · NCT06194682

• Comparing immediate and delayed surgery for ACL injuries

  This study tests whether having surgery right away or waiting to see if it's needed later is better for people with ACL injuries.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT05747079

• Measuring muscle oxygen levels during recovery from knee and hip surgery

  This study is testing a wearable sensor to see how well athletes recover from knee or hip surgery by measuring their muscle oxygen levels during physical therapy.

  Recruiting University Hospitals Cleveland Medical Center · Avon, Ohio and 1 other locations · NCT05488054

• Augmenting partial ACL tears: early outcomes

  This study will test whether ACL augmentation improves knee function in people aged 15–50 with a partial ACL tear by using the IKDC score.

  Recruiting Assiut University · Asyut · NCT05391672

• Evaluating ACL and ALL Reconstruction in Children

  This study is testing if kids who have surgery for a knee ligament injury do better when they have two ligaments fixed instead of just one.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT04825587

• National cohort study on knee issues in young people from the Faroe Islands

  This study looks at young people in the Faroe Islands who have knee problems to see how common they are and what might cause them, while also checking how these issues affect their lives.

  Recruiting Hvidovre University Hospital · Hvidovre · NCT04607538

• Montelukast for protecting cartilage after ACL surgery

  This study is testing if taking montelukast for six months after ACL surgery can help older patients reduce inflammation and protect their cartilage from damage.

  Recruiting Early Phase 1 University of Kentucky · Lexington, Kentucky · NCT04572256

• Non-surgical rehabilitation for ACL injuries

  This study tests a non-surgical rehab program for people with ACL injuries to see how well it helps them recover and whether they still need surgery.

  Recruiting Aarhus University Hospital · Aarhus N · NCT04408885

• Monitoring outcomes after ACL reconstruction surgery

  This study is tracking how well people recover after ACL surgery over five years to see what helps them heal better.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Italia · NCT03441659

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Therapeutic approach to reduce cellular aging and improve thigh muscle recovery after ACL injury

  A research project tests a drug (metformin) to help the thigh muscle heal better after ACL injury and reconstruction.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11450887

• From Knee Focus to Whole-Body Movement for ACL Injury Prevention in Teens

  A study in teens with ACL injury explores how ankle, knee, and hip movements during sports affect injury risk and lifelong joint health.

  NIH research Northwestern University · Chicago, United States · NIH-11441269

• NMES approach to protect and restore thigh muscles after ACL injury

  A researcher team at the University of Kentucky is testing how nerve-stimulating electrical therapy might prevent and reverse muscle weakness and shrinking after an ACL tear and reconstruction, with patients who have or will have ACL injuries in mind.

  NIH research University of Kentucky · Lexington, United States · NIH-11382049

• Electrical stimulation to restore quadriceps after ACL tear

  This will use neuromuscular electrical stimulation (NMES) to help people with ACL tears or reconstruction avoid quadriceps weakness and muscle loss.

  NIH research University of Kentucky · Lexington, United States · NIH-11180966

• Understanding Second ACL Injury Risk with a Smart Sensor

  This project aims to find out which factors, measured with a new wearable sensor, put adolescent athletes at risk for tearing their ACL again after surgery.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11123992

• Improving recovery after ACL injuries

  This study is looking to help people recover better from ACL injuries by figuring out the best ways to use electrical stimulation to strengthen muscles after the injury, so you can get back to your activities faster and with less risk of future problems.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11101406

• Understanding how electrical stimulation can help recover muscle function after ACL injuries

  This study is looking at how a special treatment called neuromuscular electrical stimulation can help your muscles recover better after an ACL injury, so you can get back to your normal activities faster and stronger.

  NIH research University of Kentucky · Lexington, United States · NIH-10776091

• Assessing recovery after ACL injuries using a new leg dexterity test

  This study is working on a new, easy, and safe test to check how well your leg is recovering after ACL surgery, especially for women, so that your rehab can be tailored to help you get back to your activities safely.

  NIH research Neuromuscular Dynamics, LLC · La Crescenta, UNITED STATES · NIH-10463736

Related topics

Quick answers

How many ACL Injury clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (6 trials), Italy (5 trials), Denmark (2 trials), Belgium (2 trials), Poland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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