Using PRP injections to improve recovery after ACL surgery
Platelet Rich Plasma (PRP) Treatment of the Anterior Cruciate Ligament Injured Knee to Decrease the Risk of Post-traumatic Osteoarthritis (PTOA): a Randomized Double-blind Controlled Trial
This study tests if PRP injections can help people recover better and reduce inflammation after ACL surgery compared to a placebo.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 56 (estimated) |
| Ages | 14 Years to 50 Years |
| Sex | All |
| Sponsor | Hospital for Special Surgery, New York Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT05412381 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of platelet-rich plasma (PRP) injections on reducing inflammation and improving joint function in patients who have suffered acute anterior cruciate ligament (ACL) injuries. The study involves a randomized controlled trial design, comparing PRP injections to placebo saline injections in patients undergoing ACL reconstruction. It aims to assess the short-term outcomes related to inflammation biomarkers and functional recovery, addressing the common issue of post-traumatic osteoarthritis that can develop after ACL injuries. The trial is powered based on the KOOS Jr. questionnaire, focusing on the functional outcomes of the participants.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 14-50 who have sustained an acute ACL injury within the last 6 weeks.
Not a fit: Patients with prior ACL reconstruction, significant cartilage lesions, or other ligament injuries requiring repair may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance recovery and reduce the risk of developing post-traumatic osteoarthritis in patients with ACL injuries.
How similar studies have performed: Other studies have shown promising results with PRP injections in similar contexts, suggesting potential benefits in recovery and inflammation management.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Acute ACL injury within 6 weeks of presentation * Age 14-50 * Male or female * Meniscus injury that can be treated with meniscectomy or repair (the lack of meniscus injury will not exclude patients) Exclusion Criteria: * Prior ACL reconstruction * Prior cartilage repair procedure * Prior meniscus surgery within 12 months * Prior steroid, hyaluronic acid, or PRP injection within 6 months * Other ligament injury requiring repair * Any cartilage lesion requiring repair * Any cartilage lesion greater than grade 2 (partial thickness injury) * History of inflammatory arthritis or joint sepsis * Non English speakers
Where this trial is running
New York, New York
- Hospital for Special Surgery — New York, New York, United States (Recruiting)
Study contacts
- Study coordinator: Jessica Andres-Bergos, PhD
- Email: andresbergosj@hss.edu
- Phone: (917) 260-4694
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.