Investigating the best treatments for ACL injuries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project is a pragmatic registry-based randomized controlled trial (RCT) aimed at determining the most effective treatment for anterior cruciate ligament (ACL) injuries. Participants will be randomized into two groups: one receiving early ACL surgery followed by rehabilitation, and the other undergoing active rehabilitation with the option for delayed surgery if necessary. The study leverages the Norwegian National Knee Ligament Registry (NNKLR) for data collection, which includes a comprehensive database of ACL injuries and treatments. By utilizing this established registry, the study aims to provide valuable insights into treatment effectiveness for over 4,000 patients annually in Norway.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who have sustained an acute ACL injury (must be possible to perform the "early surgery" treatment option within 12 weeks)
* Age 16-50 years and skeletally mature
* No previous surgery in the index knee or knee injury which influences rehabilitation
* Patient capable to undergo both surgery and rehabilitation

Exclusion Criteria:

• Elite athletes (Tegner 10) in pivoting sports and patients with additional knee injuries warranting repair

Where it's running

• Orthopedic Department, Akershus University Hospital
  Lørenskog, Akershus, Norway Recruiting
• Orthopedic division, Oslo University Hospital
  Oslo, Norway Recruiting

Study contacts

• Study coordinator: Rune Jakobsen, PhD/MD
• Email: r.b.jakobsen@medisin.uio.no
• Phone: 92092973

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Magic Angle Direction Imaging for ACL tears and meniscus injuries

  This study tries a new low-field MRI technique called Magic Angle Direction Imaging to see if it shows ACL tears and meniscus injuries more clearly in adults scheduled for ligament repair.

  Recruiting at 2 sites Imperial College London · London and 1 other locations · NCT07366619

• Proprioceptive exercises to aid recovery after ACL surgery

  This trial will see if adding proprioceptive exercises to standard balance training helps people aged 20–40 during the early rehab period after ACL surgery.

  Recruiting Uskudar University · Sanliurfa · NCT07333092

• Visual-guided balance training to improve knee function after ACL reconstruction

  This program tests whether adding visual-guided balance training to standard rehabilitation helps adults 18–45 recover knee function and walking after ACL reconstruction.

  Recruiting Peking University Third Hospital · Beijing · NCT07306221

• Predicting knee cartilage wear and pain after early osteoarthritis or a recent ACL injury

  This project will try to create computer models that predict cartilage damage and pain over time for people with early knee osteoarthritis or an ACL injury within the past year.

  Recruiting at 2 sites Aalborg University · Aalborg, North Denmark and 1 other locations · NCT07134244

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.