Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Perturbation Training vs Functional Activities after ACL Reconstruction

Official title: Effects of Perturbation Training Versus Task-oriented Functional Activities on Pain, Range of Motion, Balance and Function in Post-anterior Cruciate Ligament Reconstruction

Run by Riphah International University · NCT07642752 · Data updated 2026-11-12

This study tests whether perturbation training or task-oriented functional activities help people 18–45 with ACL reconstruction recover better than standard rehab.

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment54 (estimated)
SponsorRiphah International University
Academic / other
Locations1 site (Lahore, Punjab Province)
StatusRecruiting
StartedAugust 1, 2026
Main results expectedNovember 15, 2026
Study endsNovember 26, 2026
Registry record updatedSeptember 24, 2026
Trial IDNCT07642752 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are males aged 18–45, 12 weeks to 1 year post-ACL reconstruction with hamstring autograft and limited knee flexion (<120°) or mild extension lag.

Probably not a fit

Participants outside the criteria (e.g., different grafts, other knee injuries, comorbidities) may receive no added benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial compares two rehabilitation approaches after ACL reconstruction: perturbation training, which uses unexpected movements to improve stability, and task-oriented functional activities, which mimic daily or sports tasks. Participants 18–45 years old, 12 weeks to 1 year post-surgery, are randomly assigned to one of three groups: perturbation, functional activities, or standard rehab. Outcomes include pain, range of motion, knee stability, and knee function measured by standard scales. The study will be conducted at a physiotherapy clinic and a hospital in Lahore, Pakistan, enrolling 54 participants using convenience sampling.

Why it matters

Potential benefit: If successful, the findings could guide rehab choices to improve knee stability and function after ACL reconstruction.

How similar studies have gone: Previous research supports neuromuscular and functional training approaches for ACL rehab, but direct comparison in this specific post-operative window is less established.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age range: 18-45 years
* Male participants only
* History of Anterior Cruciate Ligament Reconstruction (ACLR) of 3 to 12 months
* No prior ACL surgery on the affected knee
* ACL reconstruction with autograft of hamstrings tendon
* Knee flexion range of motion less than 120°
* Extension lag less than or equal to 10°
* Pain during functional activities

Exclusion Criteria:

* Any type of fracture
* Concurrent ligamentous injury or repairable meniscus
* Osteochondral defect
* Any systemic and/or neurological illness
* Rheumatoid arthritis
* Osteomyelitis or any neurological disorders
* Spinal disorders
* Inflammatory conditions such as ankylosing spondylitis

Where it's running

  • Ghurki Hospital Lahore
    Lahore, Punjab Province, Pakistan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.