Using intraosseous morphine to manage pain during ACL reconstruction
Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction: A Randomized Control Trial
This study tests if giving morphine directly into the bone can help reduce pain and the need for other pain medications in young adults having ACL surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 84 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | The Methodist Hospital Research Institute Academic / other |
| Locations | 1 site (Houston, Texas) |
| Trial ID | NCT06511232 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of intraosseous morphine administration in reducing pain and postoperative opioid consumption in patients undergoing anterior cruciate ligament (ACL) reconstruction. The approach involves administering morphine directly into the bone to provide localized pain relief. The study focuses on patients aged 18-40 who are receiving bone-to-bone autograft for their ACL surgery. By comparing pain levels and opioid use post-surgery, the study aims to determine the benefits of this method over traditional pain management techniques.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 18-40 undergoing ACL reconstruction with bone-to-bone autograft.
Not a fit: Patients who may not benefit include those with a history of substance abuse, older than 40, or those undergoing different types of graft procedures.
Why it matters
Potential benefit: If successful, this approach could lead to reduced pain and lower reliance on opioids after ACL surgery.
How similar studies have performed: While the specific use of intraosseous morphine is less common, similar studies on localized pain management techniques have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients of the IRB approved surgeon(s) undergoing ACL reconstruction with bone-to-bone (BTB) autograft * Patients aged between 18-40 years old at the time of surgery Exclusion Criteria: * Patients undergoing ACL reconstruction with any other type of autograft or allograft other than BTB * Patients younger than 18 years old or older than 40 years old * Patients undergoing meniscal root repair or any other repair that changes their weight-bearing status * Patients with a history of substance abuse * Vulnerable populations * Patients on chronic pain medication within the last 6 months * BMI \>/= 35 * Allergy to morphine * Unwilling to participate * Any additional reason the PI deems reasonable
Where this trial is running
Houston, Texas
- Houston Methodist Research Institute — Houston, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Robert Jack, MD — The Methodist Hospital Research Institute
- Study coordinator: Haley Goble, MHA
- Email: hmgoble@houstonmethodist.org
- Phone: 713-441-3930
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.