Using intraosseous morphine to manage pain during ACL reconstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of intraosseous morphine administration in reducing pain and postoperative opioid consumption in patients undergoing anterior cruciate ligament (ACL) reconstruction. The approach involves administering morphine directly into the bone to provide localized pain relief. The study focuses on patients aged 18-40 who are receiving bone-to-bone autograft for their ACL surgery. By comparing pain levels and opioid use post-surgery, the study aims to determine the benefits of this method over traditional pain management techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of the IRB approved surgeon(s) undergoing ACL reconstruction with bone-to-bone (BTB) autograft
* Patients aged between 18-40 years old at the time of surgery

Exclusion Criteria:

* Patients undergoing ACL reconstruction with any other type of autograft or allograft other than BTB
* Patients younger than 18 years old or older than 40 years old
* Patients undergoing meniscal root repair or any other repair that changes their weight-bearing status
* Patients with a history of substance abuse
* Vulnerable populations
* Patients on chronic pain medication within the last 6 months
* BMI \>/= 35
* Allergy to morphine
* Unwilling to participate
* Any additional reason the PI deems reasonable

Where it's running

• Houston Methodist Research Institute
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Robert Jack, MD — The Methodist Hospital Research Institute
• Study coordinator: Haley Goble, MHA
• Email: hmgoble@houstonmethodist.org
• Phone: 713-441-3930

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comparing two types of grafts for knee ligament surgery

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• Proprioceptive exercises to aid recovery after ACL surgery

  This trial will see if adding proprioceptive exercises to standard balance training helps people aged 20–40 during the early rehab period after ACL surgery.

  Recruiting Uskudar University · Sanliurfa · NCT07333092

• Quadriceps tendon vs peroneus longus tendon grafts for ACL reconstruction

  This randomized trial tests whether using a quadriceps tendon autograft works as well as a peroneus longus tendon autograft for ACL reconstruction in adults, looking at knee function and donor-site effects.

  Recruiting Acibadem University · Istanbul, Besiktas · NCT07671729

• Perturbation Training vs Functional Activities after ACL Reconstruction

  This study tests whether perturbation training or task-oriented functional activities help people 18–45 with ACL reconstruction recover better than standard rehab.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07642752

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.