Comparing two types of grafts for ACL reconstruction
Official title: All Soft Tissue Quadriceps Tendon Autograft Versus Patellar Tendon Autograft in Anterior Cruciate Ligament Reconstruction: a Randomized Controlled Trial
Run by University of Alabama at Birmingham · NCT05461326 · Data updated 2026-11-12
This study is testing which type of graft, quadriceps tendon or bone-patellar tendon-bone, helps people recover better after ACL surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 14 Years to 65 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Status | Recruiting |
| Started | September 26, 2023 |
| Main results expected | June 30, 2030 |
| Study ends | June 30, 2030 |
| Registry record updated | June 10, 2026 |
| Trial ID | NCT05461326 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are skeletally mature patients under 65 years old who require ACL reconstruction and are suitable for autograft harvest.
✕Probably not a fit
Patients who are over 65, have poor tissue quality, or are not compliant with post-operative rehabilitation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to compare the effectiveness of quadriceps tendon autografts versus bone-patellar tendon-bone autografts in patients undergoing ACL reconstruction. Patients will be recruited from the Highlands Sports Medicine Clinic and will be randomized into two groups to receive either graft type. The study will assess outcomes related to recovery and performance post-surgery, with a total of 100 participants expected. The trial will ensure blinding of the research personnel and participants to maintain objectivity in the results.
Why it matters
Potential benefit: If successful, this study could help determine the optimal graft choice for ACL reconstruction, potentially improving recovery outcomes for patients.
How similar studies have gone: While there has been limited research comparing these specific graft types, previous studies have shown varying success with different autograft options in ACL reconstruction.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Skeletally mature patients younger 65 * ACL insufficiency * Scheduled to undergo autograft ACL reconstruction * Appropriate candidate for autograft harvest Exclusion Criteria: * \<14 or 65\> * Poor autograft candidate (poor tissue quality) * Multi ligamentous reconstruction (PCL, MCL, or PLC) * Pregnant or nursing * High likelihood of remaining non-compliant with physical therapy regimen * Desire to return to sport prior to 6 months * Inability to read and write English
Where it's running
-
UAB Hospital Highlands
Birmingham, Alabama, United States Recruiting
Study contacts
- Principal investigator: Amit Momaya, MD — Department of Orthopaedic Surgery, University of Alabama at Birmingham
- Study coordinator: Amit Momaya, MD
- Email: amomaya@uabmc.edu
- Phone: 864-436-0621
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.