Clinical trial Recruiting at 1 site Interventional Ages 14 to 65

Comparing two types of grafts for ACL reconstruction

Official title: All Soft Tissue Quadriceps Tendon Autograft Versus Patellar Tendon Autograft in Anterior Cruciate Ligament Reconstruction: a Randomized Controlled Trial

Run by University of Alabama at Birmingham · NCT05461326 · Data updated 2026-11-12

This study is testing which type of graft, quadriceps tendon or bone-patellar tendon-bone, helps people recover better after ACL surgery.

Quick facts

Study typeInterventional
Ages14 Years to 65 Years
SexAll
Enrollment100 (estimated)
SponsorUniversity of Alabama at Birmingham
Academic / other
Locations1 site (Birmingham, Alabama)
StatusRecruiting
StartedSeptember 26, 2023
Main results expectedJune 30, 2030
Study endsJune 30, 2030
Registry record updatedJune 10, 2026
Trial IDNCT05461326 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are skeletally mature patients under 65 years old who require ACL reconstruction and are suitable for autograft harvest.

Probably not a fit

Patients who are over 65, have poor tissue quality, or are not compliant with post-operative rehabilitation may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of quadriceps tendon autografts versus bone-patellar tendon-bone autografts in patients undergoing ACL reconstruction. Patients will be recruited from the Highlands Sports Medicine Clinic and will be randomized into two groups to receive either graft type. The study will assess outcomes related to recovery and performance post-surgery, with a total of 100 participants expected. The trial will ensure blinding of the research personnel and participants to maintain objectivity in the results.

Why it matters

Potential benefit: If successful, this study could help determine the optimal graft choice for ACL reconstruction, potentially improving recovery outcomes for patients.

How similar studies have gone: While there has been limited research comparing these specific graft types, previous studies have shown varying success with different autograft options in ACL reconstruction.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Skeletally mature patients younger 65
* ACL insufficiency
* Scheduled to undergo autograft ACL reconstruction
* Appropriate candidate for autograft harvest

Exclusion Criteria:

* \<14 or 65\>
* Poor autograft candidate (poor tissue quality)
* Multi ligamentous reconstruction (PCL, MCL, or PLC)
* Pregnant or nursing
* High likelihood of remaining non-compliant with physical therapy regimen
* Desire to return to sport prior to 6 months
* Inability to read and write English

Where it's running

  • UAB Hospital Highlands
    Birmingham, Alabama, United States
    Recruiting

Study contacts

  • Principal investigator: Amit Momaya, MD — Department of Orthopaedic Surgery, University of Alabama at Birmingham
  • Study coordinator: Amit Momaya, MD
  • Email: amomaya@uabmc.edu
  • Phone: 864-436-0621

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.