Using Twin Block anesthesia to manage pain after wisdom tooth removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of the Twin Block dental anesthetic technique in managing acute pain following third molar extractions. It aims to estimate the incidence of muscle pain in the jaw after these procedures and compare the efficacy of the Twin Block against a placebo. The study is designed as a double-blind, prospective trial, ensuring that neither the participants nor the researchers know who receives the active treatment or the placebo. This approach seeks to provide a non-opioid alternative for pain management, addressing concerns about opioid prescriptions in young adults.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients requiring extraction/s of at least 1 lower wisdom (third) molar that is partially/fully 'impacted', under intravenous sedation, are eligible to participate in this study so long as they

  1. are older than 18 years of age,
  2. are healthy,
  3. have no cognitive/intellectual disability,
  4. have no past/recent pain or reduced range of motion in their jaw joint/ muscle complex, no trauma or surgery in their jaw region.
  5. have an electronic device such as a smart phone or a tablet/ computer with internet connection.
  6. are willing to participate in the study and not be excluded by the following criteria below.

Exclusion Criteria:

* Any patients, even if satisfying the criteria above, may not take part if they have any of the following:

  1. Compromised ability to guard their self-interest, for e.g., prisoners, children, pregnant women, patients with intellectual/cognitive disability are not enrolled in the study.
  2. Those patients who present with infection/inflammation involving the third molars slated for extractions, on the day of their procedure, may not take part in the study.
  3. In addition, those who have had opioid pain medication/s in the past to address short-term or long-standing pain, or those who are on long term prescription of anti-inflammatory pain medication, are unable to participate.
  4. Those with long standing pain of the jaw joint or muscles.
  5. Finally, those patients who are allergic to/unable to tolerate either the dental local anesthetic or its components, opioids, acetaminophen ('Tylenol') or ibuprofen ('Motrin' or 'Advil') also may not take part in the study.

Where it's running

• Rutgers School of Dental Medicine
  Newark, New Jersey, United States Recruiting

Study contacts

• Principal investigator: Gayathri Subramanian, PhD, DMD — Rutgers School of Dental Medicine, Newark NJ
• Study coordinator: Gayathri Subramanian, PhD, DMD
• Email: subramga@sdm.rutgers.edu
• Phone: 973 972 3418

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.