Using liposomal bupivacaine for pain relief after lung surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the efficacy and safety of liposomal bupivacaine administered via paravertebral block for managing acute and chronic pain following video-assisted thoracoscopic lobectomy. Participants will receive either liposomal bupivacaine or standard bupivacaine before surgery and will track their pain levels at various intervals post-surgery. The study is designed as a multicenter, randomized, double-blind, controlled trial to ensure robust results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants who scheduled for elective video-assisted thoracoscopic lobectomy under general anesthesia.
* Participants were 18 years or older.
* 18 kg/m2≤BMI≤30 kg/m2
* Participants with American Society of Anesthesiology (ASA) physical status I-III.
* Understand the significance, possible benefits, potential risks of the trial in detail.Understand the procedures and methods of this study.Willing to complete the trial in strict compliance with the clinical trial protocol.Sign the informed consent form voluntarily.

Exclusion Criteria:

* with severe cardiovascular and cerebrovascular diseases such as myocardial infarction,unstable angina pectoris,severe cardiac rhythm disorders (second- and third-degree heart block,etc.), New York Heart Association (NYHA) functional class III/IV,Ischemic stroke.
* with psychiatric disorders (such as schizophrenia,depression,etc.) and cognitive impairment.
* with sensory disorders such as hyperalgesia.
* with other bodily pain.
* allergy to amide-type local anesthetics or any of the trial drugs
* taking drugs that affect liver metabolism,corticosteroids,benzodiazepines,non-steroidal anti-inflammatory drugs(NSAIDs),opioid agonist-antagonist,central-alpha 2-agonists,anticonvulsants,antidepressants within 72h.
* with a history of alcohol or opioid abuse.
* who were pregnant or lactating.
* who were currently included in another clinical study within 3 months.

Where it's running

• The Second Affiliated Hospital of Chongqing Medical University
  Chongqing, Chongqing Municipality, China Recruiting

Study contacts

• Study coordinator: He Huang, ph.D
• Email: huanghe@cqmu.edu.cn
• Phone: 86+13708385559

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Brief audio-guided mindfulness for pain in orthopedic waiting rooms

  This trial tests whether listening to short mindfulness audio clips can help reduce pain for adults waiting for orthopedic care.

  Recruiting Florida State University · Tallahassee, Florida · NCT07562412

• Comparing a single erector spinae block to parasternal plus serratus blocks for pain after sternotomy

  We will see if a single erector spinae nerve block or a combination of superficial parasternal and serratus anterior blocks better controls pain and reduces opioid use in adults having elective open‑chest (sternotomy) heart surgery.

  Recruiting Uludag University · Bursa, Nilüfer · NCT07472296

• Using pupillometry to measure acute pain in children and teens

  This project will test whether a non-invasive pupillometry device (AlgometRx Nociometer) can provide an objective measure of acute pain in children and adolescents ages 6 to 21 who are having elective surgery or undergoing bone marrow transplantation.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07336264

• Whether intense pain before emergency surgery leads to long-term pain after the operation

  We will test whether people having emergency abdominal or orthopedic surgery who have strong pain before the operation are more likely to have ongoing pain three months afterward.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06555107

• Mindfulness intervention for pain management before orthopedic procedures

  This study tests if a short mindfulness exercise can help people feel less pain before they have orthopedic procedures like kyphoplasty or radiofrequency ablation.

  Recruiting Florida State University · Tallahassee, Florida · NCT06471075

• Using a smartphone app to track pain and mood changes

  This study is testing a smartphone app to track pain and mood changes in people with chronic pain and healthy individuals to see how these factors affect pain over time.

  Recruiting Brown University · Providence, Rhode Island · NCT05754190

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.