Using magnesium infusion to manage pain in critically ill trauma patients
Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
This study is testing if giving magnesium through an IV can help manage pain and reduce the need for opioids in critically ill trauma patients in the ICU.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 156 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Sacramento, California) |
| Trial ID | NCT04166877 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of continuous intravenous administration of magnesium sulfate for pain control in trauma patients admitted to the adult Intensive Care Unit. It is a single center, double-blind, randomized controlled trial comparing magnesium sulfate to a placebo (normal saline) to assess its impact on reducing opioid requirements and pain scores. The study aims to provide an alternative non-narcotic pain management option for critically injured patients who often experience severe pain and require effective pain control.
Who should consider this trial
Good fit: Ideal candidates for this study are trauma patients aged 18-99 who are admitted to an adult intensive care unit and require pain management.
Not a fit: Patients who may not benefit include those with significant head injuries, heart failure, renal failure, or those requiring continuous opioid infusion prior to the study.
Why it matters
Potential benefit: If successful, this approach could reduce the need for narcotic pain relievers in critically ill trauma patients, leading to better pain management and fewer side effects associated with opioids.
How similar studies have performed: Other studies have shown promising results with magnesium sulfate for pain management, suggesting that this approach may be effective, although its application in critically ill trauma patients is less explored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All trauma patients admitted to an adult intensive care unit * Signed informed consent * Hospital or trauma multimodal pain management order set used for pain management * Ages 18-99 Exclusion Criteria: * Admission to the Pediatric Intensive Care Unit. * Head Abbreviated Injury Score (AIS) of greater than 1 * Known heart failure with reduced ejection fraction (EF \< 40%) * Renal failure (GFR \< 60) * Cardiac arrhythmia (except for sinus tachycardia) * Greater than 5% TBSA burn injuries * Moderate to severe alcohol withdrawal protocol ordered for patient * Regular use of opioids in the week prior to injury * Receiving continuous infusion of opioids * Patients expected to require general anesthesia between 24 and 48 hours after admission (during study drug administration) * Patients unable to provide consent is unavailable * Patients unable to provide a pain score * Pregnancy * Prisoners
Where this trial is running
Sacramento, California
- UC Davis Health — Sacramento, California, United States (Recruiting)
Study contacts
- Study coordinator: Christine S Cocanour, MD
- Email: cscocanour@ucdavis.edu
- Phone: 9167347330
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.