LY4515100 for pain after impacted wisdom tooth removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults who require extraction of two or more third molars, including two mandibular molars with partial or full bony impaction, are enrolled and must meet BMI and screening criteria. After impacted third molar removal, participants remain in a clinical research unit and receive a single oral dose of LY4515100 or placebo, with close monitoring for pain relief and safety. The study follows participants for roughly six weeks to collect acute pain outcomes and monitor adverse events. Screening includes urine drug and alcohol testing and medical history review to minimize confounding factors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant has a body mass index (BMI) between 18.5 and 35.0 kilograms per meter squared (kg/m²) inclusive.
* Participant requires extraction of 2 or more third molars, including 2 mandibular molars with partial or full bony impaction, confirmed by panoramic X-ray.

Exclusion Criteria:

* Prior dental surgery within 60 days before screening or history of other surgical procedures that could confound surgery or postoperative procedures.
* Diagnosis of chronic pain conditions that could confound postsurgical pain reporting in the opinion of the investigator.
* Positive urine drug screen or alcohol test during screening or on the day of surgery.
* Evidence or history of any other clinically significant hematological, renal, hepatic, endocrine, pulmonary, gastrointestinal, cardiovascular, psychiatric, or neurologic diseases, in the opinion of the investigator, within the last 5 years.
* History of malignancy of any organ system treated or untreated, within 5 years prior to consent. The only exceptions are previous in situ carcinoma of the cervix, localized basal cell carcinoma of the skin, or localized squamous carcinoma of the skin if the participant has been treated and is considered cured.

Where it's running

• JBR Clinical Research
  Salt Lake City, Utah, United States Recruiting

Study contacts

• Study coordinator: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
• Email: LillyTrials@Lilly.com
• Phone: 1-317-615-4559

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.