Sponsor or institution

Clinical trials and research at University of Central Florida

• 35Clinical trials
• 72NIH research projects
• 1New in 30 days
• 1Country

Newest trials

All recruiting trials (35)

• Heart Rate Variability and Rheumatoid Arthritis: What HRV Looks Like with RA

  This study checks whether continuous HRV data from an Oura ring can reflect RA disease activity in adults with RA.

  Recruiting University of Central Florida · Orlando, Florida · NCT07878975

• Anchoring and Postural Stability in Adults

  This study tests how different standing positions, including inward and outward leg anchoring, affect balance in healthy adults aged 18–50.

  Recruiting University of Central Florida · Orlando, Florida · NCT07837778

• Transitional Intervention for Hyperacusis in Autism

  Aiming to see if a transitional sound-therapy approach can help adults with autism tolerate everyday sounds better and reduce loudness-related distress.

  Recruiting University of Central Florida · Orlando, Florida and 1 other locations · NCT07798297

• Pneumococcal Carriage Duration in Young Children

  This study tests how long Streptococcus pneumoniae stays in the noses/throats of children under 4 who are followed for a year with regular swabs.

  Recruiting University of Central Florida · Orlando, Florida · NCT07748832

• Does Yoga Style Affect Sleep and Heart Health in Adults with and without Insomnia

  This study tests whether two styles of yoga (vinyasa and gentle yoga) done in the evening can improve sleep and heart health in adults, including those with insomnia.

  Recruiting University of Central Florida · Orlando, Florida · NCT07638267

• Yoga Nidra, Yoga, or no intervention for chronic low back pain

  The study tests whether Yoga Nidra or Yoga help people with chronic low back pain more than doing nothing.

  Recruiting University of Central Florida · Orlando, Florida · NCT07543835

• Pediatric referrals to summer day camps to help children from low-income families with overweight or obesity

  This project will try referring Medicaid-insured children who are overweight or obese to summer day camps to see if camp participation is a feasible and acceptable way to reduce summer weight gain.

  Recruiting University of Central Florida · Orlando, Florida · NCT07464015

• AI-personalized Medilepsy app to help teens and young adults with epilepsy manage medicines and transition to adult care

  This trial tests whether an AI-personalized Medilepsy app helps underserved adolescents and young adults with epilepsy (ages 14–24) take their anti-seizure medicines and prepare for adult care better than the standard app.

  Recruiting at 2 sites University of Central Florida · Orlando, Florida and 1 other locations · NCT07445074

• Sit Less, Move More program to increase physical activity during pregnancy

  This program will try a Fitbit-based Sit Less, Move More plan to help pregnant women under 12 weeks gestation who do less than 150 minutes of activity per week sit less and move more.

  Recruiting University of Central Florida · Orlando, Florida · NCT07223112

• UCF MammoChat mammogram image repository for AI development

  This project collects donated mammogram images and questionnaire data from adults who had breast imaging to help build and test AI that could read mammograms more accurately.

  Recruiting University of Central Florida · Orlando, Florida · NCT07214883

• Follicular fluid microRNAs and ovarian aging linked to IVF outcomes

  This project will test whether tiny RNA molecules (exosomal microRNAs) in the fluid around eggs can indicate egg quality and predict IVF success for women under 31 or over 38 undergoing IVF.

  Recruiting University of Central Florida · Orlando, Florida · NCT07214246

• Health effects of red tide and cyanobacteria blooms in Florida

  This project will compare how often adults who live, work, or visit certain Florida counties have respiratory and other symptoms during red tide or cyanobacteria bloom periods to see if exposure leads to more health problems.

  Recruiting University of Central Florida · Multiple Locations, Florida · NCT07091058

• Quadriceps response to simulated knee injury

  This project will test whether filling the knee with fluid or temporarily numbing its nerves changes quadriceps muscle recruitment in healthy 18–30-year-olds.

  Recruiting Early Phase 1 University of Central Florida · Orlando, Florida · NCT06999057

• How the menstrual cycle affects immune responses and recovery after exercise in women

  This study is testing how different phases of the menstrual cycle affect immune responses and recovery after exercise in healthy women aged 18-40.

  Recruiting University of Central Florida · Orlando, Florida · NCT06985420

• Brain biobank for research on brain diseases

  This study is setting up a brain bank to collect donated brains after death to help researchers find better ways to diagnose and treat brain diseases like Alzheimer's and dementia.

  Recruiting University of Central Florida · Orlando, Florida · NCT06876857

• Biobank for civilian astronauts and extreme environment travelers

  This study is collecting health samples and information from civilian astronauts and people who live in extreme environments to see how these conditions affect their health.

  Recruiting University of Central Florida · Orlando, Florida · NCT06781424

• Biobank for human tissue collection and research

  This study is collecting tissue samples from people having surgery to help researchers at the University of Central Florida improve medical research and treatments.

  Recruiting University of Central Florida · Orlando, Florida · NCT06781411

• Effects of Resveratrol on Exercise Performance and Recovery

  This study is testing if taking a daily supplement of resveratrol can help young men who lift weights recover better and feel less sore after intense workouts.

  Recruiting University of Central Florida · Orlando, Florida · NCT06723119

• Assessing diet and activity capabilities in diabetes management

  This study looks at how diet, exercise, and knowledge about diabetes affect the health of adults with diabetes in Central Florida, especially those who have been in the hospital before.

  Recruiting University of Central Florida · Orlando, Florida · NCT06631105

• Investigating language development in children with communication challenges

  This study is testing new ways to measure language growth in preschoolers with communication challenges, like Down Syndrome and Cerebral Palsy, to see what helps them learn to talk better.

  Recruiting University of Central Florida · Orlando, Florida · NCT06512168

• Gut bacteria in Huntington disease

  This project will try to see if adults with Huntington's disease who worsen quickly have different gut bacteria than those who progress more slowly.

  Recruiting University of Central Florida · Orlando, Florida · NCT06448546

• Examining pneumococcal carriage in children and adults after the pandemic

  This study is trying to see how the types of pneumococcal bacteria in children and adults have changed after the COVID-19 pandemic by collecting samples from their noses.

  Recruiting University of Central Florida · Orlando, Florida · NCT06373328

• Study on how diet affects autoimmune diseases in rheumatology patients

  This study looks at how changing to a healthier diet, like the Mediterranean diet, might help people with autoimmune diseases feel better and manage their symptoms.

  Recruiting University of Central Florida · Orlando, Florida · NCT06339957

• Financial and counseling support for transgender women to improve health services access

  This study tests whether financial help and personalized counseling can make it easier for transgender women to access substance use services and HIV prevention methods like PrEP.

  Recruiting University of Central Florida · Orlando, Florida · NCT06202898

• Understanding trust-related decisions in healthy aging

  This study looks at how trust decisions change as people get older by comparing younger adults to older adults through some tasks and surveys.

  Recruiting University of Central Florida · Orlando, Florida · NCT06176092

• Improving HIV care for formerly incarcerated individuals through legal aid

  This study tests whether providing legal help can improve HIV care for people who have been in jail by training healthcare workers to better understand and support their needs.

  Recruiting University of Central Florida · Orlando, Florida · NCT06171919

• Using cell-free DNA to diagnose pancreatic cancer

  This study is testing whether a new blood test that looks at cell-free DNA can help diagnose pancreatic cancer earlier and more easily than current methods.

  Recruiting University of Central Florida · Orlando, Florida · NCT06148298

• HIV prevention program for Latino male couples

  This study is testing a program to help Latino male couples learn how to better protect themselves from HIV and see if it makes a difference over nine months.

  Recruiting University of Central Florida · Orlando, Florida · NCT06131931

• Contact registry for people interested in clinical trials

  This study is setting up a registry for people who want to learn about and join clinical trials at the University of Central Florida College of Medicine without sharing their personal health details.

  Recruiting University of Central Florida · Orlando, Florida · NCT06084312

• Using blood samples to find biomarkers for Huntington Disease

  This study is trying to find signs in blood samples that could help track Huntington Disease by looking at tiny particles released from brain cells in people with the disease compared to healthy individuals.

  Recruiting University of Central Florida · Orlando, Florida · NCT06082713

• Collection of de-identified human tissue for medical research

  This study is collecting anonymous human tissue samples to help researchers learn more about diseases and create better treatments.

  Recruiting University of Central Florida · Orlando, Florida · NCT06082687

• Blood collection from healthy adult volunteers

  This study is collecting blood samples from healthy adults to help researchers at the University of Central Florida learn more about diseases and develop new ways to diagnose and treat them.

  Recruiting University of Central Florida · Orlando, Florida · NCT06082661

• Investigating immune responses in allergic asthma

  This study is trying to see if certain immune responses are linked to allergic asthma by testing how cells react to different allergens in people with allergies or asthma compared to healthy individuals.

  Recruiting University of Central Florida · Orlando, Florida · NCT06068335

• Using digital technology to manage chemotherapy-related nausea and vomiting in older adults

  This study is testing a digital program to help older adults manage nausea and vomiting while they go through chemotherapy to see if it improves their quality of life.

  Recruiting at 2 sites University of Central Florida · Miami, Florida and 1 other locations · NCT05838638

• A project examining health and wellness in the Lake Nona community

  This study looks at how different health habits affect the well-being and longevity of people living in the Lake Nona community over time.

  Recruiting University of Central Florida · Orlando, Florida · NCT02533804

NIH-funded research (newest 40 of 72)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Sexually Transmitted Infection Testing Risk and Prevention among Trans Women

  A study to improve STI testing and prevention for trans women by testing self-collection vs clinician collection, and by measuring STI prevalence across sites and how social factors influence risk.

  NIH research University of Central Florida · Orlando, United States · NIH-11581928

• Collaborative AI for safer, faster bacteremia care

  A physician-centered AI system is being built to help diagnose and treat bloodstream infections more accurately and safely, with the goal of reducing sepsis deaths.

  NIH research University of Central Florida · Orlando, United States · NIH-11579169

• Bayesian data tools to map and fight syphilis and congenital syphilis

  A data-driven, bayesian approach will turn messy health data into clear, local-level insights to prevent congenital syphilis and reduce syphilis in communities.

  NIH research University of Central Florida · Orlando, United States · NIH-11575522

• Harnessing neuron-derived vesicles to find Huntington’s disease biomarkers

  A research project aims to identify brain-derived biomarkers in blood that reflect Huntington disease activity, using neuronal extracellular vesicles as the signal source.

  NIH research University of Central Florida · Orlando, United States · NIH-11448886

• Heart nerves: mapping how the heart’s sensing nerves connect in health and diabetes

  This project maps the nerve pathways that sense heart signals in healthy and diabetic hearts to identify targets for therapies that could reduce heart injury.

  NIH research University of Central Florida · Orlando, United States · NIH-11414963

• Strengths-based suicide prevention for Black sexual minority youth

  A research project aims to help Black sexual minority youth reduce suicidal thoughts and behaviors by understanding protective factors and risks in everyday life.

  NIH research University of Central Florida · Orlando, United States · NIH-11411146

• Measuring voice tiredness in the lab and everyday life

  This project uses wearable sensors, lab recordings, and machine learning to track how vocal tiredness builds up and recovers in adults who rely on their voice.

  NIH research University of Central Florida · Orlando, United States · NIH-11393450

• State laws and ED care to start opioid treatment sooner

  This grant aims to map and study how state ED policies affect starting opioid use disorder treatment like buprenorphine right after emergency visits, to help more patients get lifesaving care sooner.

  NIH research University of Central Florida · Orlando, United States · NIH-11386496

• Next-generation antimalarials targeting Plasmodium kinases

  A researcher team will design and test new type II kinase inhibitors to fight malaria by hitting parasite enzymes and blocking multiple stages of the parasite’s life cycle.

  NIH research University of Central Florida · Orlando, United States · NIH-11380710

• Using strengths to prevent suicide in Black sexual minority youth

  This project uses personal and community strengths plus daily tracking to help reduce suicidal thoughts in Black sexual minority youth ages 13–26.

  NIH research University of Central Florida · Orlando, United States · NIH-11367889

• Vital capacity and airflow for voice care using a vortex whistle

  A team at the University of Central Florida is creating an inexpensive vortex whistle and software to measure breathing and airflow during voice use, helping clinicians evaluate voice disorders in children.

  NIH research University of Central Florida · Orlando, United States · NIH-11367349

• Serious gaming to help older adults prevent and manage chemotherapy-induced nausea

  A game-based education program helps people 65 and older manage nausea from cancer treatment at home.

  NIH research University of Central Florida · Orlando, United States · NIH-11364953

• When Plastic Meets Flow: How Microplastics Might Harm the Blood Vessel Lining

  This research looks at whether microplastics in the bloodstream could disrupt the lining of blood vessels and contribute to heart and stroke risks, and tests possible antioxidant or anti-inflammatory therapies.

  NIH research University of Central Florida · Orlando, United States · NIH-11360537

• Using medium-chain fatty acids and a fat-sensing receptor to treat chronic graft-versus-host disease

  This project looks at whether changing medium‑chain fatty acids or blocking a fat sensor called GPR84 can help people with chronic graft‑versus‑host disease after a bone marrow/stem cell transplant.

  NIH research University of Central Florida · Orlando, United States · NIH-11325709

• How inherited Alzheimer's mutations change nerve and muscle function

  Looks at how inherited Alzheimer's mutations affect human nerve and muscle cells to see whether early movement changes could signal future Alzheimer's risk.

  NIH research University of Central Florida · Orlando, United States · NIH-11314595

• Tracking language growth for people who use picture-based communication devices

  This project is developing reliable tools to measure how children and adults who use picture symbols and communication devices learn and use language.

  NIH research University of Central Florida · Orlando, United States · NIH-11301927

• How the brain coordinates both hands when they work together

  This project looks at how adults’ brains coordinate both hands during shared tasks to help guide better therapies for people after stroke or other brain injuries.

  NIH research University of Central Florida · Orlando, United States · NIH-11290311

• Couples-focused HIV prevention program

  A brief three-session program for adult couples to learn about HIV prevention options like PrEP and treatment and get support to use them consistently.

  NIH research University of Central Florida · Orlando, United States · NIH-11251327

• Social stress, cellular aging, and early birth risk in Black women

  This project looks at whether life stress and a DNA-based measure of cellular aging are linked to having a baby before 37 weeks among Black pregnant women.

  NIH research University of Central Florida · Orlando, United States · NIH-11238952

• A new biosensor for detecting HIV and Hepatitis viruses in low-resource areas

  This study is working on a new, easy-to-use test that can quickly check for HIV, Hepatitis B, and Hepatitis C all at once, especially in places where medical resources are limited, to help more people get diagnosed and treated sooner.

  NIH research University of Central Florida · Orlando, United States · NIH-11187332

• Boosting lubricin to protect knees after ACL and other knee injuries

  Researchers are trying to find FDA-approved drugs that raise lubricin, a natural joint lubricant, to help people with knee injuries like ACL tears avoid post-traumatic osteoarthritis.

  NIH research University of Central Florida · Orlando, United States · NIH-11170609

• Understanding how the brain processes sound in noisy environments

  This study is looking at how our brains help us hear in noisy places and how things like getting older or having some hearing loss can make that harder, especially for people who might not realize they have a problem yet; the goal is to find ways to improve hearing aids and help people hear better in everyday situation

  NIH research University of Central Florida · Orlando, United States · NIH-11169441

• Targeted IL-2 to reduce lung inflammation and boost immunity in severe flu

  A targeted form of the immune protein IL-2 is being developed to calm dangerous lung inflammation and strengthen immunity for people with severe influenza and related respiratory virus infections.

  NIH research University of Central Florida · Orlando, United States · NIH-11160543

• Developing New Medicines for Tuberculosis

  This project is looking for new and better medicines to treat tuberculosis, a serious infection that affects many people worldwide.

  NIH research University of Central Florida · Orlando, United States · NIH-11140519

• Using Motor Imagery to Improve Speech After Stroke

  This project explores a new computer-based home practice program to help people with speech difficulties after a stroke speak more clearly.

  NIH research University of Central Florida · Orlando, United States · NIH-11131290

• A new tool for measuring breathing and airflow for voice problems

  This project is creating an affordable, easy-to-use device to help speech-language pathologists better understand breathing and airflow for people with voice problems.

  NIH research University of Central Florida · Orlando, United States · NIH-11129798

• 3D building blocks of noncoding RNA

  Using computer-vision-inspired methods to map tiny 3D RNA building blocks that can affect health for people with RNA-related conditions.

  NIH research University of Central Florida · Orlando, United States · NIH-11129320

• Malaria medicines that target parasite protein kinases

  Researchers are developing new malaria medicines that block parasite enzymes called kinases to treat and prevent infections, especially in children and areas with drug-resistant malaria.

  NIH research University of Central Florida · Orlando, United States · NIH-11121847

• A game to help older adults with cancer manage nausea and vomiting from chemotherapy

  This project explores if a special computer game can help older adults with cancer feel better and manage nausea and vomiting after chemotherapy.

  NIH research University of Central Florida · Orlando, United States · NIH-11120850

• A body and mind program to prevent falls in older adults

  This program helps low-income older adults prevent falls by combining balance exercises with mental strategies to manage fear of falling.

  NIH research University of Central Florida · Orlando, United States · NIH-11118931

• Understanding how a bacterial toxin damages DNA and its link to cancer

  This study is looking at how a toxin from certain bacteria can harm DNA in human cells, which might lead to cancer, and it's for anyone interested in understanding how this process works so we can find better ways to treat toxin-related cancers.

  NIH research University of Central Florida · Orlando, United States · NIH-11114069

• Investigating how medium chain fatty acids affect chronic graft-versus-host disease

  This study is looking at how certain fatty acids might affect T cells and contribute to chronic graft-versus-host disease (cGVHD) after stem cell transplants, with the hope of finding new ways to help patients feel better.

  NIH research University of Central Florida · Orlando, United States · NIH-11092858

• Using drug treatment to prevent sexually transmitted infections in women who use drugs

  This study is looking at how getting help for drug use can lower the chances of women getting sexually transmitted infections (STIs), especially for those who don’t inject drugs, and it aims to find better ways to support these women in accessing treatment.

  NIH research University of Central Florida · Orlando, United States · NIH-11085056

• Investigating how a protein helps the body sense and respond to airborne allergens

  This study is looking at how a protein called LMAN1 helps the body recognize allergens in the air that can cause asthma symptoms, with the hope of finding new ways to prevent or treat asthma for those who are sensitive to these triggers.

  NIH research University of Central Florida · Orlando, United States · NIH-11079541

• Exploring how genetic mutations in Alzheimer's disease affect muscle and nerve function

  This study is looking at how certain genetic changes linked to Alzheimer's disease might affect movement and muscle function, helping us understand if early signs of trouble with movement can predict memory problems later on, which could help identify people at risk for Alzheimer's before they show major symptoms.

  NIH research University of Central Florida · Orlando, United States · NIH-11079448

• Using type I interferon to enhance immune memory against influenza

  This study is looking at how a special protein called type I interferon can help boost the immune response of important lung cells that fight off the flu, with the goal of finding better ways to improve flu vaccines.

  NIH research University of Central Florida · Orlando, United States · NIH-11078793

• Developing better ways to measure language development in individuals using communication devices

  This study is working on creating better ways to measure how well people who use communication devices, like picture symbols, are developing their language skills, so that they can get the right support and help they need.

  NIH research University of Central Florida · Orlando, United States · NIH-11056068

• Understanding how antimicrobial peptides can break down the protective capsule of Klebsiella pneumoniae

  This study is looking at how special proteins can break through the protective layer of a tough germ called Klebsiella pneumoniae, which is hard to treat with regular antibiotics, to help find better ways to fight infections for patients.

  NIH research University of Central Florida · Orlando, United States · NIH-11055963

• Enhancing blood test accuracy using new technology

  This study is exploring a new way to make blood tests for conditions like cancer more accurate and sensitive by using tiny particles that act like enzymes, which could help doctors catch diseases earlier.

  NIH research University of Central Florida · Orlando, United States · NIH-11055328

• Understanding how people perceive voice quality changes

  This study is looking at how both patients and doctors understand and judge voice quality, especially for those with voice disorders, to create better tools for diagnosing and treating these conditions.

  NIH research University of Central Florida · Orlando, United States · NIH-11044993

Quick answers

How many clinical trials run by University of Central Florida are recruiting right now?

35, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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