Exploring how genetic mutations in Alzheimer's disease affect muscle and nerve function
Official title: Investigating the role of Alzheimer's disease familial mutations in neuromuscular physiology
Funded at University of Central Florida · NIH-11079448 · Data updated 2026-11-12
This study is looking at how certain genetic changes linked to Alzheimer's disease might affect movement and muscle function, helping us understand if early signs of trouble with movement can predict memory problems later on, which could help identify people at risk for Alzheimer's before they show major symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Central Florida NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project start | May 15, 2022 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $728,632 |
| NIH project number | 5R01AG077651-04 |
| Project ID | NIH-11079448 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those showing early signs of cognitive impairment.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without a familial link to the condition may not benefit from this research.
What this research studies
This research investigates the impact of familial mutations associated with Alzheimer's disease on neuromuscular physiology. By developing a preclinical model that focuses on motor function, the study aims to understand how early motor impairments can predict cognitive decline in Alzheimer's patients. The approach involves using human cells to evaluate the effects of amyloid and tau proteins on the peripheral nervous system. This could lead to identifying biomarkers for patients at high risk of developing Alzheimer's before significant cognitive symptoms appear.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management strategies for individuals at risk of Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using motor function as an early indicator of cognitive decline in Alzheimer's, suggesting that this approach could be effective.
Where this research is happening
-
University of Central Florida
Orlando, United States Active
Researchers
- Principal investigator: Guo, Xiufang — University of Central Florida
- Study coordinator: Guo, Xiufang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.