Follicular fluid microRNAs and ovarian aging linked to IVF outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study that will collect follicular fluid during IVF cycles and isolate exosomal microRNAs for high-throughput sequencing. Researchers will compare miRNA expression profiles between younger (<31) and older (>38) women and correlate identified signatures with oocyte quality and IVF outcomes. Validated exosome isolation and sequencing methods will be used, followed by gene-target and pathway analyses to interpret biological relevance. Findings will be compared with existing preclinical data and may be validated in additional samples.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women undergoing IVF treatment due to male factor infertility or nonovarian causes.
* Age groups: younger women \<31 years and older women \>38 years.
* Regular menstrual cycles.
* Willing and able to provide informed consent.

Exclusion Criteria:

* Minors (under 18 years) and women aged 32-37 years
* Diagnosis of polycystic ovarian syndrome (PCOS).
* History of recurrent pregnancy loss.
* Presence of endometriosis.
* Diagnosis of ovarian insufficiency.
* Metabolic disorders (e.g., diabetes).
* History of ovarian surgery or chemotherapy.
* Any condition that might impact follicular fluid quality or IVF outcomes.

Where it's running

• University of Central Florida
  Orlando, Florida, United States Recruiting

Study contacts

• Principal investigator: Michal Masternak, PhD — University of Central Florida
• Study coordinator: Amoy Fraser, PhD, CCRP, PMP
• Email: Amoy.Fraser@ucf.edu
• Phone: 4072668742

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• How a mother's immune system accepts pregnancy in the first trimester

  We will test how the immune system changes in the first trimester in people undergoing IVF to see which immune patterns support implantation and help prevent early miscarriage.

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• Ovarian PRP injections to try to improve embryo quality

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• Using Super-GDF9 to Improve Oocyte Quality in In Vitro Fertilization

  This study is testing if adding Super-GDF9 can help improve egg quality during a specific fertility treatment for women with PCOS who are looking for a safer and more affordable alternative to traditional IVF.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City · NCT06766604

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.