Investigating how a protein helps the body sense and respond to airborne allergens
Cell surface LMAN1 as a General Sensor and Negative Regulator of Mannosylated Aeroallergens
This study is looking at how a protein called LMAN1 helps the body recognize allergens in the air that can cause asthma symptoms, with the hope of finding new ways to prevent or treat asthma for those who are sensitive to these triggers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Central Florida NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project ID | NIH-11079541 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called LMAN1 in recognizing airborne allergens, which can trigger asthma symptoms. By studying how LMAN1 interacts with these allergens in the airway, researchers aim to uncover the mechanisms behind allergic responses and asthma development. The project involves laboratory experiments to analyze how LMAN1 functions as a receptor and its impact on immune responses. This could lead to new insights into preventing or treating asthma in sensitized individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced allergic reactions or asthma symptoms related to airborne allergens.
Not a fit: Patients who do not have allergies or asthma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or managing asthma triggered by airborne allergens.
How similar studies have performed: Other research has shown promising results in understanding immune responses to allergens, making this approach a continuation of established scientific inquiry.
Where this research is happening
Orlando, United States
- University of Central Florida — Orlando, United States (Active)
Researchers
- Principal investigator: Tigno-Aranjuez, Justine Tiglao — University of Central Florida
- Study coordinator: Tigno-Aranjuez, Justine Tiglao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.