Effects of Resveratrol on Exercise Performance and Recovery
The Effects of Resveratrol Supplementation on Functional and Systemic Markers of Muscle Damage and Cardiovascular Function in Response to a Damaging Isoinertial Squat Protocol
This study is testing if taking a daily supplement of resveratrol can help young men who lift weights recover better and feel less sore after intense workouts.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Male |
| Sponsor | University of Central Florida Academic / other |
| Locations | 1 site (Orlando, Florida) |
| Trial ID | NCT06723119 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of daily supplementation with 500mg of VeriSperse® resveratrol over 17 days on muscle function and recovery in resistance-trained young adult males. Participants will undergo a randomized, counterbalanced, crossover design, completing 13 visits to the Exercise Physiology Intervention and Collaboration (EPIC) lab. The study will assess muscle soreness, markers of muscle damage, and oxidative stress following a damaging squat protocol. Blood samples and hydration assessments will be conducted to evaluate the physiological effects of the supplementation.
Who should consider this trial
Good fit: Ideal candidates are healthy male individuals aged 18-40 who are recreationally active and have been resistance training for at least six months.
Not a fit: Patients who are not male, outside the age range, or not engaged in regular resistance training may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance exercise performance and recovery for athletes and active individuals.
How similar studies have performed: While there have been studies on resveratrol's effects, this specific approach and population may provide novel insights into its impact on exercise performance.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Male between the ages of 18-40 years old * Healthy, and ready for physical activity as determined by the PAR-Q+, and MHQ. * Participants will be required to be recreationally active (defined according to ACSM standards of at least 150 minutes exercise per week). * Participants will be required to have been actively resistance training for a minimum of 6 months as defined by 3 resistance training sessions per week with at least one lower body session. * Participants must be willing to abstain from the consumption of bananas of non-steroidal anti-inflammatory drugs (NSAIDs) for the duration of their enrollment in study. * Participants must be willing to abstain from dietary supplementation that are viewed by study investigators to confound the outcomes of the study (e.g., Creatine). Those currently supplementing must be willing to undergo a 28-day washout prior to beginning study procedures. * Participants must be consuming \<300 mg·day-1 (Equivalent to 3 cups of coffee per day or 2 16oz cans of Redbull) and willing to keep their caffeine consumption consistent throughout the duration of the study. * Participants will be required to have access to the online MyFitnessPal application either via cellphone or computer and be willing to download and maintain the application for the duration of the study. * Free from previous or current lower body injuries that are viewed by the investigators to potentially limit ability of the participant to perform the assessments. * Willing to abstain from lower body resistance training for the 14 days preceding ET1 and ET2 Exclusion Criteria: * • Individual does not provide consent to participate in this study. * Inability to perform physical exercise (determined by MHQ, and PAR Q+). That is Answering "Yes" to any question on the PAR-Q +, or having a pre-existing condition such as musculoskeletal injury, back pain, chronic pain etc. that the investigative team perceives will prevent a participant from safely completing the protocol. * Not currently participating in at least 150 minutes of physical activity per week. * Not currently resistance trained (as defined within the inclusion criteria) * Currently taking any performance-enhancing drug (determined from health and activity questionnaire) * Currently taking a nutritional supplement known to improve physical performance and not willing refrain form the consumption of the supplement for at least 28-days prior to beginning study procedures. * Regularly taking any type of prescription or over-the-counter medication deemed to affect performance, or having any chronic illnesses, which require medical care. * Have used nicotine or tobacco at any time within the last three months. * Report consuming bananas or NSAIDS at any time during your enrollment in the study. * Report daily caffeine consumption \>300 mg·day-1 * Report any lower extremity muscle soreness for visits ET1 and ET2 * Previous or current lower body injuries viewed by the investigators to potentially limit the ability of the participant to perform the assessments. * Inability or unwillingness to consume the provided standardized snacks and meals in their entirety. * Inability or unwillingness to adhere to the diet restrictions of the study. * Have a food allergy to either of the two provided energy bars. * Inability or unwillingness to report all food and beverage consumption during the two 5-day dietary log periods.
Where this trial is running
Orlando, Florida
- University of Central Florida EPIC Lab — Orlando, Florida, United States (Recruiting)
Study contacts
- Study coordinator: Trevor Dufner
- Email: trevor.dufner@ucf.edu
- Phone: 701-205-8690
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.