Investigating immune responses in allergic asthma
Innate Immunity in Allergic Asthma
This study is trying to see if certain immune responses are linked to allergic asthma by testing how cells react to different allergens in people with allergies or asthma compared to healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Central Florida Academic / other |
| Locations | 1 site (Orlando, Florida) |
| Trial ID | NCT06068335 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between a specific immune response, known as a type 2 signature, and allergic or asthmatic conditions. Researchers will stimulate cell lines with various allergens in a laboratory setting to identify patterns in cell surface receptor expression, pathway activation, and gene upregulation. The findings will help determine if these immune responses correlate with the presence of allergic diseases or asthma in individuals. The study will include healthy controls as well as participants with diagnosed allergies or asthma.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with either clinically diagnosed allergies or asthma, as well as healthy individuals without a history of allergic disease.
Not a fit: Patients who are pregnant, prisoners, or currently suffering from acute infections will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of allergic asthma and lead to improved diagnostic and therapeutic strategies.
How similar studies have performed: While the specific approach of this study is novel, similar studies investigating immune responses in asthma have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants must be at least 18 years of age * no history of allergic disease (healthy controls), have clinically diagnosed allergies, or have clinically diagnosed asthma. Exclusion Criteria: * Pregnant women and prisoners will be excluded from the study. * Individuals currently suffering from any acute infections and those known to suffer from light-headedness will be excluded.
Where this trial is running
Orlando, Florida
- University of Central Florida — Orlando, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Justine T Tigno-Aranjuez, PhD — University of Central Florida
- Study coordinator: Amoy Fraser, PhD, CCRP, PMP
- Email: amoy.fraser@ucf.edu
- Phone: 4072668742
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.