Using cell-free DNA to diagnose pancreatic cancer
Official title: Cell-free Chromatin Immunoprecipitation (CfChIP) from Blood Plasma As a Diagnostic and Prognostic Tool in Pancreatic Ductal Adenocarcinoma
Run by University of Central Florida · NCT06148298 · Data updated 2026-11-12
This study is testing whether a new blood test that looks at cell-free DNA can help diagnose pancreatic cancer earlier and more easily than current methods.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | University of Central Florida Academic / other |
| Locations | 1 site (Orlando, Florida) |
| Status | Recruiting |
| Started | May 24, 2023 |
| Main results expected | May 2025 |
| Study ends | May 2025 |
| Registry record updated | December 6, 2024 |
| Trial ID | NCT06148298 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have been diagnosed with pancreatic cancer.
✕Probably not a fit
Patients who are under 18 years old or unable to provide consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to utilize chromatin immunoprecipitation (ChIP) to analyze cell-free DNA for diagnosing and prognosing pancreatic ductal adenocarcinoma (PDAC). By focusing on protein-DNA interactions, the study seeks to identify tumor-specific transcriptional activity in human samples. Given the high mortality rate associated with late-stage PDAC, this approach could provide a non-invasive and cost-effective alternative to traditional screening methods like MRI. The study emphasizes the potential of liquid biopsy techniques to enhance early detection and improve patient outcomes.
Why it matters
Potential benefit: If successful, this method could lead to earlier and more accurate diagnoses of pancreatic cancer, potentially improving survival rates.
How similar studies have gone: While few studies have explored the use of ChIP in liquid biopsies for pancreatic cancer, other liquid biopsy approaches have shown promise, indicating potential for success in this novel application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years old or older * Pancreatic cancer patients Exclusion Criteria: * Children may not register * Persons who are unable to consent may not register
Where it's running
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University of Central Florida
Orlando, Florida, United States Recruiting
Study contacts
- Principal investigator: Kersten Schroeder, PhD — University of Central Florida
- Study coordinator: Amoy Fraser, PhD, CCRP, PMP
- Email: amoy.fraser@ucf.edu
- Phone: 4072668742
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.