Using type I interferon to enhance immune memory against influenza
Official title: Harnessing type I interferon to promote lung-resident memory CD4 T cell immunity against influenza
Funded at University of Central Florida · NIH-11078793 · Data updated 2026-11-12
This study is looking at how a special protein called type I interferon can help boost the immune response of important lung cells that fight off the flu, with the goal of finding better ways to improve flu vaccines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Central Florida NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project start | June 21, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $757,303 |
| NIH project number | 4R01AI167994-04 |
| Project ID | NIH-11078793 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals at risk of influenza infection, particularly those with weakened immune systems or chronic respiratory conditions.
✕Less likely to help
Patients who are not at risk for influenza or those who have already developed strong immunity to the virus may not benefit from this research.
What this research studies
This research investigates how type I interferon can enhance the immune response of CD4 T cells that reside in the lungs, which are crucial for fighting off influenza infections. By studying mouse models, the researchers aim to understand the signals that promote the development of these memory T cells, which are essential for long-lasting immunity. The project will explore both direct effects of type I interferon on T cells and its indirect effects through the inflammatory environment, ultimately aiming to improve vaccine strategies against influenza.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide long-lasting protection against influenza.
How similar studies have gone: Previous research has shown promise in using type I interferon to enhance immune responses, suggesting that this approach could be effective.
Where this research is happening
-
University of Central Florida
Orlando, United States Active
Researchers
- Principal investigator: Mckinstry, Karl Kai — University of Central Florida
- Study coordinator: Mckinstry, Karl Kai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.