Pneumococcal Carriage Duration in Young Children
Official title: NIS103487 Duration of Streptococcus Pneumoniae Carriage in U.S. Children Under Five: A Pilot Longitudinal Study
Run by University of Central Florida · NCT07748832 · Data updated 2026-11-12
This study tests how long Streptococcus pneumoniae stays in the noses/throats of children under 4 who are followed for a year with regular swabs.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 28 Days to 48 Months |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University of Central Florida Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Orlando, Florida) |
| Status | Recruiting |
| Started | July 21, 2026 |
| Main results expected | July 2027 |
| Study ends | July 2027 |
| Registry record updated | August 6, 2026 |
| Trial ID | NCT07748832 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are children aged 28 days to under 4 years whose parent/guardian can consent, read English or Spanish, and commit to 12 months of biweekly OP swabs.
✕Probably not a fit
Children with chronic illnesses or immunocompromising conditions, or those unable to comply with the 12-month sampling schedule, may not benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study tracks pneumococcal carriage over 12 months in young children to estimate how long colonization lasts and to explore patterns of co-colonization and interactions with viruses and the respiratory microbiome. High-resolution sampling and genomic methods will be used to generate updated carriage estimates in a U.S. pediatric population. Oropharyngeal swabs are collected biweekly, with caregiver questionnaires to understand factors that may influence carriage. The study aims to inform future pneumococcal vaccine strategies and public health planning.
Why it matters
Potential benefit: If successful, the study could improve understanding of carriage duration and microbial interactions, potentially guiding vaccine development and public health interventions.
How similar studies have gone: Previous studies have used longitudinal sampling and genomic methods to study pneumococcal carriage, supporting the feasibility of this approach in children.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Are older than 28 days and under 4 years of age at the time of enrollment. * Have a parent or legal guardian who: 1. Provides written informed consent. 2. Is able to read and speak English or Spanish. 3. Agrees to comply with all study procedures, including completion of questionnaires and biweekly oropharyngeal (OP) swab collections from the child for a period of 12 months. Exclusion Criteria: * History of chronic medical conditions or immunocompromising conditions that may influence pneumococcal carriage or study participation, such as: * cystic fibrosis * cerebral palsy * neuromuscular disorders * congenital heart disease * known congenital or acquired immunodeficiencies * sickle cell disease * undergoing immunosuppressive therapy (e.g., systemic corticosteroids ≥2 mg/kg/day for ≥14 days, chemotherapy, biologics)
Where it's running
-
University of Central Florida
Orlando, Florida, United States Recruiting
Study contacts
- Principal investigator: Dr. Taj Azarian, PhD — University of Central Florida
- Study coordinator: Dr. Amoy Fraser, PhD
- Email: Amoy.Fraser@UCF.edu
- Phone: 407-266-8742
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Assessing the effectiveness of a new pneumococcal vaccine in healthy adults
This study is testing a new pneumococcal vaccine to see if it helps healthy adults aged 18-50 fight off an infection caused by a specific bacteria.
-
Examining pneumococcal carriage in children and adults after the pandemic
This study is trying to see how the types of pneumococcal bacteria in children and adults have changed after the COVID-19 pandemic by collecting samples from their noses.
-
Heart Rate Variability and Rheumatoid Arthritis: What HRV Looks Like with RA
This study checks whether continuous HRV data from an Oura ring can reflect RA disease activity in adults with RA.
-
Anchoring and Postural Stability in Adults
This study tests how different standing positions, including inward and outward leg anchoring, affect balance in healthy adults aged 18–50.
-
Transitional Intervention for Hyperacusis in Autism
Aiming to see if a transitional sound-therapy approach can help adults with autism tolerate everyday sounds better and reduce loudness-related distress.
-
Does Yoga Style Affect Sleep and Heart Health in Adults with and without Insomnia
This study tests whether two styles of yoga (vinyasa and gentle yoga) done in the evening can improve sleep and heart health in adults, including those with insomnia.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.