Sponsor or institution
Clinical trials and research at Hospital for Special Surgery
As of November 12, 2026, Find a Trial lists 46 NIH-funded research projects at this institution, with $24.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 46NIH research projects
NIH-funded research (newest 40 of 46)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Subjective thinking challenges in adults with lupus as they age
This grant aims to understand how lupus-related cognitive problems affect adults, especially older adults, and tests a real-time method to track daily fluctuations in those symptoms.
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How bone density and joint loads affect implant migration after knee replacement
A knee replacement project explores how bone density and how the knee is loaded relate to early implant movement that could lead to loosening.
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ctDNA biomarker to guide safety of cancer immunotherapy in inflammatory arthritis
A patient-facing biomarker study using a blood test to detect tumor DNA in people with cancer who develop inflammatory arthritis from immunotherapy, to help doctors pick safer treatment choices.
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Glucocorticoid-regulated transcription networks in macrophage biology
A scientist-led project will study how stress-related hormones and immune signals control macrophages, which are key players in inflammation and tissue repair.
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Targeting bone-resorbing osteoclasts with cell-specific therapies
A doctor-research team is exploring a new way to treat bone diseases by targeting the blood-forming cells that become osteoclasts, aiming to reduce bone loss and side effects for patients.
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Osteoclast programming and reprogramming during bone formation and disease
A research project explores how bone-resorbing cells called osteoclasts are controlled at the genetic level to find ways to prevent or slow bone loss in conditions like osteoporosis and rheumatoid arthritis.
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Langerhans cells and skin lymphatics in lupus immunity
A study in adults with lupus aims to understand how skin immune cells and the skin’s drainage system influence overall autoimmune flares.
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Understanding how to slow bone destruction in inflammatory arthritis
This NIH grant studies how inflammation drives bone loss and tests new ways to stop osteoclasts from breaking down bone in conditions like rheumatoid arthritis.
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Type I interferon and treatment response in rheumatoid arthritis
A doctor-scientist team is studying how a specific immune signal, type I interferon, affects which rheumatoid arthritis treatments work best for patients.
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Macrophages in autoimmune joint disease and personalized RA therapies
This NIH grant explores why people with rheumatoid arthritis respond differently to treatments by studying macrophages in affected joints.
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Understanding how B cells go rogue in lupus (SLE) in both sexes
This grant studies why B cells behave abnormally in lupus, a disease that mostly affects women, to help identify new ways to treat or prevent it.
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How lymphatic flow affects immune activity in lupus
The team is working to improve lymphatic flow to lower skin sensitivity and harmful immune activity in people with systemic lupus (SLE).
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How the molecule Malat1 helps keep bones strong
This project is seeing if the molecule called Malat1 helps bone cells stay balanced to prevent bone loss in people with conditions like osteoporosis and Albers-Schonberg disease.
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How a DNA region on chromosome 12 may raise lupus risk
This project looks at whether small DNA differences near genes change immune-cell behavior in people with lupus and related interferon-driven responses.
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Imaging bone growth to predict limb length in kids and young adults
Aims to use advanced MRI diffusion imaging to better predict how long a child’s leg bone will grow and how it might become misaligned after injury or toward adulthood.
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Restoring immune balance in rheumatoid arthritis
This work looks at how immune cells in inflamed joints make damaging signals and aims to shift those signals to help people with rheumatoid arthritis.
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How RBP-J controls bone loss in arthritis
This work aims to understand how the protein RBP-J and the enzyme Hs2st1 control inflammation-driven bone loss in people with rheumatoid arthritis.
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Macrophages and inflammation in autoimmune arthritis
This project looks at how macrophages (a type of immune cell) become 'trained' to produce inflammatory signals in people with autoimmune arthritis so better treatments can be developed.
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How glucocorticoid steroid hormones shape macrophage behavior
This work looks at how common steroid hormones called glucocorticoids change macrophages—the immune cells that clear dying cells—to help people with conditions like diabetic wounds, atherosclerosis, and autoimmune diseases.
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How inflammation changes bone-building cells and bone repair
This work looks at whether turning down an overactive interferon-related signal in bone-forming cells can help people with inflammatory bone loss, such as rheumatoid arthritis, rebuild bone.
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Understanding and Controlling Bone Loss
This research explores how inflammation causes excessive bone loss in conditions like arthritis and joint infections, aiming to find new ways to protect your bones.
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Understanding skin and immune system links in lupus
This research explores how skin issues and the immune system are connected in people with lupus, especially regarding sun sensitivity.
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Understanding bone-resorbing cells to treat bone diseases
This work aims to uncover how bone-resorbing cells, called osteoclasts, are controlled, which could lead to new ways to help people with conditions like osteoporosis and rheumatoid arthritis.
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Understanding how a specific immune signal affects rheumatoid arthritis treatment
This work explores how a signal in your blood might help doctors choose the best treatment for rheumatoid arthritis.
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Using MRI Bone Texture to Predict Complications After Spine Fusion Surgery
This project looks at whether a new way to analyze MRI scans can help predict bone quality and potential problems for people having spine fusion surgery.
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Understanding how certain immune cells contribute to lupus
This study is looking at how certain types of B cells, especially a new group called Age/Autoimmune-associated B cells, behave in people with lupus, with the goal of finding new ways to help treat the disease.
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Understanding how joint cells contribute to rheumatoid arthritis
This research explores how certain cells in the joints cause inflammation and damage in rheumatoid arthritis, hoping to find new ways to help patients.
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How developmental signals keep spinal discs healthy
This research looks at whether a developmental signal called sonic hedgehog (SHH) helps keep adult spinal discs healthy and prevents age-related disc breakdown.
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Understanding how inflammation affects bone formation
This study is looking at how inflammation affects bone growth in people with rheumatoid arthritis, aiming to find ways to help boost bone formation by understanding the role of certain proteins and cells involved.
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Understanding the role of immune cells in Duchenne muscular dystrophy
This study is looking at how certain immune cells called macrophages affect muscle inflammation and healing in people with Duchenne muscular dystrophy (DMD), with the hope of finding new ways to help improve treatment for those living with this condition.
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Understanding how certain cells contribute to rheumatoid arthritis
This study is looking at how certain cells in your joints, called synovial fibroblasts, get activated and contribute to rheumatoid arthritis, with the goal of finding new ways to help improve treatment for people living with this condition.
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Understanding how certain molecules affect the health of spinal discs as we age
This study is looking at how certain molecules help keep the discs in your spine healthy and how their decline as we age might lead to back pain, with the goal of finding new ways to treat these issues for adults dealing with chronic lower back pain.
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Investigating genetic factors that increase the risk of autoimmune diseases like lupus
This study is looking at how certain genes might affect the immune system in people with lupus, with the hope that understanding these genetic factors can help create better treatments for the disease.
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How a specific RNA affects bone health and repair
This study is looking at how a special molecule called Malat1 helps keep our bones healthy by balancing the work of cells that break down bone and those that build it, which could lead to better ways to prevent bone diseases like osteoporosis and rheumatoid arthritis.
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Controlling Inflammation and Promoting Tissue Repair
This project aims to understand how immune cells called macrophages help balance inflammation and tissue repair in the body.
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Understanding immune cell interactions in systemic sclerosis
This study is looking at how immune cells and skin cells work together in people with systemic sclerosis to find out what causes skin thickening, with the hope of creating better, personalized treatments to help improve your health.
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Understanding how to control bone loss caused by inflammation
This study is looking at how inflammation from conditions like rheumatoid arthritis can lead to too much bone loss, and it's trying to find new ways to help people keep their bones healthy.
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Understanding how social factors affect pregnancy outcomes in women with lupus
This study looks at how things like race and income can affect pregnancy outcomes for women with lupus, using data from many pregnancies to help understand the risks and challenges they might face.
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Understanding how skin immune cells affect autoimmune responses in lupus
This study is looking at how certain skin cells and the flow of lymphatic fluid affect people with lupus, especially how these factors might lead to skin problems and flare-ups when exposed to sunlight, with the goal of finding new ways to help improve treatment for patients.
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Understanding how bone-resorbing cells develop and function
This study is looking at how certain genes control the bone-eating cells called osteoclasts, which play a big role in conditions like osteoporosis and rheumatoid arthritis, to help create better treatments for these bone-related diseases.
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