Understanding how certain immune cells contribute to lupus
Mechanisms controlling ABC differentiation and function in SLE
This study is looking at how certain types of B cells, especially a new group called Age/Autoimmune-associated B cells, behave in people with lupus, with the goal of finding new ways to help treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project ID | NIH-11097209 on NIH RePORTER |
What this research studies
This research investigates the role of specific B cell subsets in the development of systemic lupus erythematosus (SLE), a complex autoimmune disease that primarily affects women. The study focuses on understanding the molecular mechanisms that lead to the abnormal behavior of these B cells, particularly a newly identified subset known as Age/Autoimmune-associated B cells (ABCs). By examining how these cells are regulated and how they contribute to the production of autoantibodies, the research aims to uncover potential new therapeutic targets for treating SLE. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with systemic lupus erythematosus, particularly women, as they are disproportionately affected by the disease.
Not a fit: Patients with autoimmune conditions other than lupus or those without a diagnosis of SLE may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively manage or even prevent lupus and its associated complications.
How similar studies have performed: Previous research has shown promising results in understanding B cell behavior in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, UNITED STATES
- Hospital for Special Surgery — New York, United States (Active)
Researchers
- Principal investigator: Pernis, Alessandra B — Hospital for Special Surgery
- Study coordinator: Pernis, Alessandra B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.