Understanding how to control bone loss caused by inflammation
Negative Regulation of Osteoclastogenesis
This study is looking at how inflammation from conditions like rheumatoid arthritis can lead to too much bone loss, and it's trying to find new ways to help people keep their bones healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project ID | NIH-10998475 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that lead to excessive bone loss due to the activity of osteoclasts, which are cells that break down bone tissue. By focusing on the role of inflammation in conditions like rheumatoid arthritis and infections, the project aims to identify new therapeutic strategies to inhibit harmful bone resorption. The researchers will explore molecular pathways and epigenetic factors that influence osteoclast function, particularly under inflammatory conditions. This work is crucial for developing effective treatments for patients suffering from conditions that cause significant bone loss.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from inflammatory conditions such as rheumatoid arthritis or those at risk of bone loss due to infections.
Not a fit: Patients with non-inflammatory bone loss conditions or those not experiencing significant bone resorption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively prevent or reduce bone loss in patients with inflammatory diseases.
How similar studies have performed: Previous research has shown promise in understanding the mechanisms of osteoclastogenesis and its regulation, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
New York, UNITED STATES
- Hospital for Special Surgery — New York, United States (Active)
Researchers
- Principal investigator: Ivashkiv, Lionel B — Hospital for Special Surgery
- Study coordinator: Ivashkiv, Lionel B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.