Controlling Inflammation and Promoting Tissue Repair
Official title: Inhibition of STAT3 and inflammatory cytokine production
Funded at Hospital for Special Surgery · NIH-11015783 · Data updated 2026-11-12
This project aims to understand how immune cells called macrophages help balance inflammation and tissue repair in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | September 30, 1999 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $431,650 |
| NIH project number | 5R01AI044938-25 |
| Project ID | NIH-11015783 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with chronic inflammatory conditions, such as certain types of arthritis, might eventually benefit from this research.
✕Less likely to help
Patients whose conditions are not related to macrophage-driven inflammation or cytokine production may not directly benefit from this specific approach.
What this research studies
Macrophages are important immune cells that play a key role in healing, fighting infections, and resolving inflammation. Sometimes, these cells can cause too much inflammation, as seen in chronic conditions like certain types of arthritis, which can prevent proper healing. This research seeks to understand how macrophages switch between causing inflammation and helping tissues repair themselves. The ultimate goal is to find ways to guide these cells to reduce harmful inflammation and encourage better healing and tissue restoration.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that reduce chronic inflammation and improve tissue repair for various inflammatory diseases.
How similar studies have gone: While the role of macrophages in inflammation is well-known, this research explores new ways to therapeutically guide their functions for better healing.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Ivashkiv, Lionel B — Hospital for Special Surgery
- Study coordinator: Ivashkiv, Lionel B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.