Understanding how a specific immune signal affects rheumatoid arthritis treatment
Type I interferon Impacts Treatment Response in Rheumatoid Arthritis
This work explores how a signal in your blood might help doctors choose the best treatment for rheumatoid arthritis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project ID | NIH-11126052 on NIH RePORTER |
What this research studies
Rheumatoid arthritis can be challenging to treat because it's hard to know which medication will work best for each person. This project focuses on a specific immune signal, called type I interferon (T1IFN), found in the blood before treatment. We believe that measuring this signal could help predict if a common medication, called a TNF inhibitor, will be effective for you. By studying blood and joint samples, we aim to understand how this signal influences the disease and treatment response, ultimately helping doctors personalize care.
Who could benefit from this research
Good fit: This research is relevant for patients with rheumatoid arthritis, particularly those considering or currently receiving TNF inhibitor treatments.
Not a fit: Patients whose rheumatoid arthritis is well-controlled with current treatments or who are not candidates for TNF inhibitors may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a blood test that helps doctors choose the most effective rheumatoid arthritis treatment for you from the start, avoiding ineffective therapies.
How similar studies have performed: Previous work by this team has shown promising results in predicting non-response to TNF inhibitors based on pre-treatment immune signals, suggesting this approach has a strong foundation.
Where this research is happening
New York, UNITED STATES
- Hospital for Special Surgery — New York, United States (Active)
Researchers
- Principal investigator: Wampler Muskardin, Theresa — Hospital for Special Surgery
- Study coordinator: Wampler Muskardin, Theresa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.