How a specific RNA affects bone health and repair
Official title: Regulation of bone homeostasis and remodeling by long noncoding RNA Malat1
Funded at Hospital for Special Surgery · NIH-11042217 · Data updated 2026-11-12
This study is looking at how a special molecule called Malat1 helps keep our bones healthy by balancing the work of cells that break down bone and those that build it, which could lead to better ways to prevent bone diseases like osteoporosis and rheumatoid arthritis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | July 1, 2021 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $417,595 |
| NIH project number | 5R01AR078212-04 |
| Project ID | NIH-11042217 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with osteoporosis, rheumatoid arthritis, or other bone-related disorders.
✕Less likely to help
Patients with acute bone injuries or those not suffering from chronic bone diseases may not benefit from this research.
What this research studies
This research investigates the role of a long noncoding RNA called Malat1 in maintaining bone health and remodeling. It focuses on understanding how Malat1 influences the balance between bone resorption by osteoclasts and bone formation by osteoblasts, which is crucial for preventing conditions like osteoporosis and rheumatoid arthritis. By studying animal models, the research aims to uncover the mechanisms by which Malat1 regulates these processes, potentially leading to new diagnostic and therapeutic strategies for bone diseases.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for bone disorders, improving bone health and reducing the risk of fractures in patients.
How similar studies have gone: Other research has shown promising results in targeting long noncoding RNAs for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Zhao, Baohong — Hospital for Special Surgery
- Study coordinator: Zhao, Baohong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.