Macrophages in autoimmune joint disease and personalized RA therapies
Official title: Macrophages in human autoimmune tissue pathology
Funded at Hospital for Special Surgery · NIH-11363794 · Data updated 2026-11-12
This NIH grant explores why people with rheumatoid arthritis respond differently to treatments by studying macrophages in affected joints.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | June 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $569,219 |
| NIH project number | 2R01AI148435-06A1 |
| Project ID | NIH-11363794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with rheumatoid arthritis whose joints are being studied or sampled for research.
✕Less likely to help
Some patients may not experience noticeable changes in treatment guidance from this research.
What this research studies
Researchers at a major hospital will study how different macrophage types in RA joints relate to treatment responses. They will analyze tissue samples to identify macrophage states linked to fibrosis and wound healing, aiming to map endotypes within RA. The project hopes to link molecular patterns in synovial tissue to which therapies work best for individual patients.
Why it matters
Potential benefit: Understanding patient-specific pathways could lead to more effective, personalized RA treatments.
How similar studies have gone: Prior AMP and related studies suggest distinct RA endotypes; this project builds on those findings but remains to be validated in broader populations.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Donlin, Laura T. — Hospital for Special Surgery
- Study coordinator: Donlin, Laura T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.