Osteoclast programming and reprogramming during bone formation and disease
Official title: Osteoclast programming and reprogramming during osteoclastogenesis
Funded at Hospital for Special Surgery · NIH-11377664 · Data updated 2026-11-12
A research project explores how bone-resorbing cells called osteoclasts are controlled at the genetic level to find ways to prevent or slow bone loss in conditions like osteoporosis and rheumatoid arthritis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | September 20, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $432,342 |
| NIH project number | 5R01AR083374-04 |
| Project ID | NIH-11377664 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with osteoporosis, rheumatoid arthritis, or cancers that metastasize to bone may benefit if therapies emerge from this research.
✕Less likely to help
People without bone diseases may see indirect benefits, but direct patient therapies may not be available during the study period.
What this research studies
This project investigates how osteoclasts, the cells that break down bone, are regulated by specific DNA regions known as super-enhancers and by non-coding RNAs. By analyzing human osteoclasts, researchers aim to identify targets that could lead to osteoclast-specific therapies with fewer side effects. The study uses genome-wide analyses to map regulatory elements and understand how signals like RANKL shape osteoclast identity. The ultimate goal is to translate these insights into new strategies to protect bone health in patients.
Why it matters
Potential benefit: If successful, the work could yield osteoclast-specific treatment targets to slow or halt bone loss with reduced risk of unintended effects.
How similar studies have gone: Prior research has linked enhancer regulation to cell identity in osteoclasts, with promising but early translational potential.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Park-Min, Kyung-Hyun — Hospital for Special Surgery
- Study coordinator: Park-Min, Kyung-Hyun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.