Understanding how joint cells contribute to rheumatoid arthritis
Official title: Cytokine regulation of RA synoviocyte phenotype
Funded at Hospital for Special Surgery · NIH-11085938 · Data updated 2026-11-12
This research explores how certain cells in the joints cause inflammation and damage in rheumatoid arthritis, hoping to find new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | September 27, 1999 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $379,852 |
| NIH project number | 5R01AR046713-25 |
| Project ID | NIH-11085938 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with rheumatoid arthritis who are interested in the underlying causes of their condition and future treatment options may find this research relevant.
✕Less likely to help
Patients seeking immediate new treatments or direct participation in a clinical trial may not directly benefit from this foundational research.
What this research studies
In rheumatoid arthritis, special cells in your joints, called synovial cells, produce inflammatory signals that make the disease worse. This project aims to understand exactly how these signals activate other cells in the joint and attract immune cells, driving the inflammation and joint damage. By learning more about these processes, we hope to discover new and safer treatments that can specifically target the root causes of inflammation in rheumatoid arthritis.
Why it matters
Potential benefit: If successful, this work could lead to the development of more effective and safer treatments for rheumatoid arthritis by targeting specific inflammatory pathways.
How similar studies have gone: While specific approaches may be novel, understanding cytokine roles in inflammation is a well-established area of research with prior successes in developing therapies for autoimmune diseases.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Ivashkiv, Lionel B — Hospital for Special Surgery
- Study coordinator: Ivashkiv, Lionel B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.