Glucocorticoid-regulated transcription networks in macrophage biology
Funded at Hospital for Special Surgery · NIH-11394557 · Data updated 2026-11-12
A scientist-led project will study how stress-related hormones and immune signals control macrophages, which are key players in inflammation and tissue repair.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | April 1, 2014 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $697,595 |
| NIH project number | 5R01DK099087-12 |
| Project ID | NIH-11394557 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with autoimmune conditions or metabolic diseases where macrophage behavior and efferocytosis play a role may benefit from future applications of these findings.
✕Less likely to help
This basic science project may not directly benefit patients in the short term and is primarily discovery-driven.
What this research studies
This project explores how glucocorticoids affect macrophage behavior at the genetic level, aiming to map the transcription networks that control inflammatory and healing responses. By examining transcription factors and cofactors like GR, KLF4, and GRIP1, researchers hope to understand how macrophages become pro- or anti-inflammatory. The work uses patient-relevant biology, including human macrophage activity, to reveal mechanisms that could influence autoimmune and metabolic diseases. Results could guide new ways to modulate inflammation and improve tissue repair.
Why it matters
Potential benefit: If successful, the research could lead to better strategies to control inflammation and promote healing in autoimmune and metabolic conditions.
How similar studies have gone: Previous research has shown macrophage polarization and efferocytosis are linked to disease outcomes, with some success in translating transcriptional insights to therapies.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Rogatsky, Inez — Hospital for Special Surgery
- Study coordinator: Rogatsky, Inez
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.