Understanding how to slow bone destruction in inflammatory arthritis
Official title: Negative Regulation of Osteoclastogenesis
Funded at Hospital for Special Surgery · NIH-11377415 · Data updated 2026-11-12
This NIH grant studies how inflammation drives bone loss and tests new ways to stop osteoclasts from breaking down bone in conditions like rheumatoid arthritis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $551,137 |
| NIH project number | 5R01AR084248-17 |
| Project ID | NIH-11377415 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people with inflammatory arthritis or patients at risk for inflammatory bone loss who may benefit from future therapies derived from this research.
✕Less likely to help
Patients without inflammatory bone loss or related conditions may not directly benefit from this line of research.
What this research studies
If funded, researchers will explore the molecular signals that control bone-resorbing cells during inflammation and test new strategies to suppress their activity. The work builds on prior findings about epigenetic and metabolic controls of osteoclast formation in arthritis and implant-related bone loss. It aims to translate these basic insights into potential therapies that reduce pathological bone loss where current treatments fall short. The project includes models of inflammatory bone loss such as rheumatoid arthritis and orthopedic infections to assess potential treatments in relevant settings.
Why it matters
Potential benefit: Potentially new therapies could better prevent bone loss and joint damage in inflammatory diseases and after joint replacement.
How similar studies have gone: Previous work showed that inflammation and hypoxia regulate osteoclast formation, supporting the relevance of this approach; translation to therapies remains ongoing.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Ivashkiv, Lionel B — Hospital for Special Surgery
- Study coordinator: Ivashkiv, Lionel B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.