Understanding how bone-resorbing cells develop and function
Osteoclast programming and reprogramming during osteoclastogenesis
['FUNDING_R01'] · HOSPITAL FOR SPECIAL SURGERY · NIH-10932429
This study is looking at how certain genes control the bone-eating cells called osteoclasts, which play a big role in conditions like osteoporosis and rheumatoid arthritis, to help create better treatments for these bone-related diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HOSPITAL FOR SPECIAL SURGERY (nih funded) |
| Locations | 1 site (New York, UNITED STATES) |
| Trial ID | NIH-10932429 on ClinicalTrials.gov |
What this research studies
This research investigates the differentiation and regulation of osteoclasts, which are cells responsible for bone resorption. By focusing on specific genetic and epigenetic factors, the study aims to identify unique regulatory elements known as super-enhancers that are crucial for osteoclast function. The researchers will utilize advanced techniques, including ATAC sequencing and CRISPR methods, to explore these regulatory mechanisms and their implications for diseases like osteoporosis and rheumatoid arthritis. The goal is to develop targeted therapies that can effectively manage or prevent bone-related diseases by specifically addressing osteoclast activity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with osteoporosis, rheumatoid arthritis, or conditions involving excessive bone resorption.
Not a fit: Patients with bone diseases unrelated to osteoclast activity or those without significant bone resorption issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted treatments for patients suffering from bone diseases, potentially improving their quality of life.
How similar studies have performed: Previous research has shown promise in targeting specific regulatory elements in other cell types, suggesting that this approach could be effective for osteoclasts as well.
Where this research is happening
New York, UNITED STATES
- HOSPITAL FOR SPECIAL SURGERY — New York, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARK-MIN, KYUNG-HYUN — HOSPITAL FOR SPECIAL SURGERY
- Study coordinator: PARK-MIN, KYUNG-HYUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bone Diseases