Understanding how bone-resorbing cells develop and function
Official title: Osteoclast programming and reprogramming during osteoclastogenesis
Funded at Hospital for Special Surgery · NIH-10932429 · Data updated 2026-11-12
This study is looking at how certain genes control the bone-eating cells called osteoclasts, which play a big role in conditions like osteoporosis and rheumatoid arthritis, to help create better treatments for these bone-related diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | September 20, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $469,728 |
| NIH project number | 5R01AR083374-02 |
| Project ID | NIH-10932429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with osteoporosis, rheumatoid arthritis, or conditions involving excessive bone resorption.
✕Less likely to help
Patients with bone diseases unrelated to osteoclast activity or those without significant bone resorption issues may not benefit from this research.
What this research studies
This research investigates the differentiation and regulation of osteoclasts, which are cells responsible for bone resorption. By focusing on specific genetic and epigenetic factors, the study aims to identify unique regulatory elements known as super-enhancers that are crucial for osteoclast function. The researchers will utilize advanced techniques, including ATAC sequencing and CRISPR methods, to explore these regulatory mechanisms and their implications for diseases like osteoporosis and rheumatoid arthritis. The goal is to develop targeted therapies that can effectively manage or prevent bone-related diseases by specifically addressing osteoclast activity.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted treatments for patients suffering from bone diseases, potentially improving their quality of life.
How similar studies have gone: Previous research has shown promise in targeting specific regulatory elements in other cell types, suggesting that this approach could be effective for osteoclasts as well.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Park-Min, Kyung-Hyun — Hospital for Special Surgery
- Study coordinator: Park-Min, Kyung-Hyun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.