Understanding how inflammation affects bone formation
Official title: Mechanisms of inflammatory osteoblastogenesis and bone formation
Funded at Hospital for Special Surgery · NIH-11071571 · Data updated 2026-11-12
This study is looking at how inflammation affects bone growth in people with rheumatoid arthritis, aiming to find ways to help boost bone formation by understanding the role of certain proteins and cells involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $688,634 |
| NIH project number | 1R01AG092357-01A1 |
| Project ID | NIH-11071571 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are experiencing chronic inflammatory conditions such as rheumatoid arthritis.
✕Less likely to help
Patients with non-inflammatory bone loss conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the mechanisms by which inflammation impacts the formation of bone, particularly in conditions like rheumatoid arthritis. It focuses on the role of specific proteins and cellular responses that inhibit the development of bone-forming cells called osteoblasts. By exploring these mechanisms, the research aims to identify potential therapeutic targets to enhance bone formation in patients suffering from chronic inflammatory diseases. The study utilizes advanced genetic and molecular techniques to uncover the underlying biological processes involved.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve bone formation and reduce bone loss in patients with inflammatory conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in bone health, suggesting that this approach could yield significant insights.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Zhao, Baohong — Hospital for Special Surgery
- Study coordinator: Zhao, Baohong
Related research
Other NIH-funded projects on the same topics.
-
Subjective thinking challenges in adults with lupus as they age
This grant aims to understand how lupus-related cognitive problems affect adults, especially older adults, and tests a real-time method to track daily fluctuations in those symptoms.
-
How bone density and joint loads affect implant migration after knee replacement
A knee replacement project explores how bone density and how the knee is loaded relate to early implant movement that could lead to loosening.
-
ctDNA biomarker to guide safety of cancer immunotherapy in inflammatory arthritis
A patient-facing biomarker study using a blood test to detect tumor DNA in people with cancer who develop inflammatory arthritis from immunotherapy, to help doctors pick safer treatment choices.
-
Glucocorticoid-regulated transcription networks in macrophage biology
A scientist-led project will study how stress-related hormones and immune signals control macrophages, which are key players in inflammation and tissue repair.
-
Targeting bone-resorbing osteoclasts with cell-specific therapies
A doctor-research team is exploring a new way to treat bone diseases by targeting the blood-forming cells that become osteoclasts, aiming to reduce bone loss and side effects for patients.
-
Osteoclast programming and reprogramming during bone formation and disease
A research project explores how bone-resorbing cells called osteoclasts are controlled at the genetic level to find ways to prevent or slow bone loss in conditions like osteoporosis and rheumatoid arthritis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.