Understanding and Controlling Bone Loss
Official title: Negative Regulation of Osteoclastogenesis
Funded at Hospital for Special Surgery · NIH-11143228 · Data updated 2026-11-12
This research explores how inflammation causes excessive bone loss in conditions like arthritis and joint infections, aiming to find new ways to protect your bones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $522,312 |
| NIH project number | 5R01AR084248-16 |
| Project ID | NIH-11143228 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is not directly recruiting patients, but its findings could eventually benefit individuals experiencing bone loss due to inflammatory conditions such as rheumatoid arthritis or periprosthetic joint infections.
✕Less likely to help
Patients whose bone loss is not related to excessive osteoclast activity or inflammatory conditions may not directly benefit from this specific line of research.
What this research studies
Many health issues that lead to significant bone loss are linked to too many bone-resorbing cells, called osteoclasts. This project seeks to uncover the specific ways these cells are controlled, especially when inflammation is present. Current treatments often don't work well for bone loss driven by inflammation, such as in rheumatoid arthritis or infections after joint replacement surgery. By understanding these processes better, we hope to develop new and more effective treatments to prevent bone damage.
Why it matters
Potential benefit: If successful, this work could lead to new medications or strategies to prevent or slow down bone loss in patients with inflammatory conditions like arthritis and joint infections.
How similar studies have gone: This project builds upon previous work that identified epigenetic and metabolic mechanisms involved in osteoclast formation, testing their importance in models of inflammatory bone loss.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Ivashkiv, Lionel B — Hospital for Special Surgery
- Study coordinator: Ivashkiv, Lionel B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.