Sponsor or institution
Clinical trials and research at Hennepin Healthcare Research Institute
As of November 12, 2026, Find a Trial lists 10 clinical trials run by Hennepin Healthcare Research Institute that are recruiting, at sites in 4 countries (most in United States (9), Canada (1), Nepal (1)). 1 was first registered in the last 30 days. By phase: Phase 2 (1), Phase 4 (1). There are also 37 NIH-funded research projects at this institution, with $28.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 10Clinical trials
- 37NIH research projects
- 1New in 30 days
- 4Countries
Newest trials
All recruiting trials (10)
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Vibratory Genital Nerve Stimulation to Help Female Sexual Function After Spinal Cord Injury
This study tests whether a home-use vibration device can improve sexual function in cisgender women with spinal cord injury by increasing genital blood flow during arousal.
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Depth Electrode Monitoring after Traumatic Brain Injury
This study tests adding a depth electrode with continuous brain monitoring during external ventricular drain placement in adults with traumatic brain injury to see if cortical reverberation signals can be tracked safely.
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Diabetes medication and wellness coaching for adults who have recently experienced homelessness
This program tests whether 10 wellness coaching sessions (D-HOMES) help English- or Spanish-speaking adults with type 2 diabetes and A1c ≥7.5% who have recently experienced homelessness do better than a one-time education session.
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Comparing waveform capnography and color-change CO2 detectors to confirm tube placement during intubation
This study will test whether waveform capnography or color-change CO2 detectors better confirm endotracheal tube placement in critically ill adults during intubation.
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Neovent bilevel ventilation for newborns in low-resource hospitals
This project will test whether the Neovent, a low-cost bilevel breathing support device, helps newborns with mild to moderate respiratory distress in low-resource hospitals.
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Tracking vaccine responses in older adults living with HIV
This study is testing how well a pneumonia vaccine works over time in older adults living with HIV compared to younger people, to see if age and HIV affect their immune response.
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Counseling intervention for kidney transplant candidates
This study is testing whether group education and counseling for kidney transplant candidates can improve their support and well-being compared to those who only fill out a survey.
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Head‑up, device‑assisted controlled elevation CPR for out‑of‑hospital cardiac arrest
This registry will track how head‑up, device‑assisted CPR (using an impedance threshold device plus either active compression‑decompression or mechanical compressions) works for adults who experience out‑of‑hospital cardiac arrest.
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Understanding brain activity after severe traumatic brain injury
This study is trying to understand brain activity in patients with severe traumatic brain injuries to see how certain brain changes might affect recovery and help find better treatments.
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Hyperbaric oxygen treatment for severe brain injury
This study is testing different ways of using hyperbaric oxygen treatment to see if it can help people with severe brain injuries feel better.
NIH-funded research (37)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Sex-specific blood biomarkers predict dementia risk in older adults
This NIH project tests how blood biomarkers and sex differences predict future dementia in older people, with the goal of personalized prognosis and prevention.
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Sex-specific blood biomarkers to predict Alzheimer's and related dementias
This project aims to use blood biomarkers to predict risk of Alzheimer's-related conditions in older adults, with attention to how sex differences may change risk.
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How blood tests and risk factors differ by sex for Alzheimer's and related dementias
This project looks at blood tests (amyloid, tau, and neurodegeneration markers) and other risk factors in older men and women to help spot who may develop Alzheimer's or related dementias.
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A learning system to boost organ donation and strengthen community ties
A nationwide effort using a learning health system to help more people donate organs and to reduce disparities in who gets transplants.
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Vaccine responses in older people living with HIV
This project looks at how age and HIV infection affect how well a pneumococcal vaccine works, especially in older adults.
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A tool to help decide kidney transplants for people who had cancer
A patient-friendly tool will help doctors and patients understand how kidney transplant may affect survival for people with end-stage kidney disease who have a history of cancer.
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Hyperbaric oxygen treatment to help severe brain injury
A study testing whether giving high-pressure oxygen right after a severe brain injury can improve brain recovery and outcomes.
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Boosting T and B cell responses to malaria with IL-15
This project tests whether a natural immune signal called IL-15 can strengthen and lengthen protection from malaria vaccines and infections in adults.
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How pregnant e-cigarette use may affect children's brains and addiction risk
This project looks at whether mothers' e-cigarette use during pregnancy changes their children's behavior and brain circuits linked to addiction.
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How blood tests and risk factors predict Alzheimer's differently in men and women
This project looks at blood markers and known risk factors to predict Alzheimer's and related dementias in older men and women.
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NorthStar network for improving substance use disorder care
This program runs clinical trials to test new treatments and care approaches for people with substance use disorders, with attention to groups often left out of research.
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Helping people without stable housing manage type 2 diabetes medicines
A program that offers up to 10 one-on-one coaching sessions over three months to help adults who have experienced homelessness take their type 2 diabetes medicines and improve wellbeing.
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Making malaria vaccines work better using mice with human-like immune systems
Scientists are testing whether adding an immune-boosting ingredient to a whole-parasite malaria vaccine can produce stronger, longer-lasting protection for adults at risk of malaria.
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Kidney transplant decisions for people who've had cancer
This project will build a tool to help people with kidney failure who had cancer understand whether a transplant might help them live longer than staying on dialysis.
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A Blood Test to Understand Memory Changes in Diabetes
This project explores how a blood test might help us understand and predict memory changes in older adults living with diabetes.
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Hyperbaric Oxygen for Brain Injury
This research explores if giving extra oxygen in a special chamber can help people recover better after a severe brain injury.
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Vaccine protection and inflammation in older adults with HIV
This project looks at how age and long-term inflammation change immune responses to the pneumococcal vaccine in adults with and without HIV.
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Community learning system to boost organ donation and engagement
This project builds a community-linked learning system to increase organ donation and support Native American and other minority communities facing transplant shortages.
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Investigating blood biomarkers and risk factors for Alzheimer's disease in men and women
This study is looking at how different factors for men and women might affect the chances of developing Alzheimer's and related memory issues, using blood tests to spot those at higher risk before they show any symptoms, so we can help with early diagnosis and prevention.
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Exploring a new malaria vaccine using specially treated mice
This study is looking at how well a malaria vaccine works by using special mice that react like humans do, and it aims to find ways to boost the vaccine's effectiveness, especially for people living in areas where malaria is common.
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Improving diabetes management for homeless individuals
This study is testing a program called D-HOMES that helps people experiencing homelessness manage their diabetes better by offering personalized support from a health coach, with sessions available in English and Spanish, to tackle challenges they face in taking their medication and staying healthy.
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How maternal e-cigarette exposure affects addiction in children
This study looks at how being around e-cigarette smoke during pregnancy might affect a child's behavior and brain development, especially in terms of attention and impulse control, to help understand the risks for moms and their babies.
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Virtual coaching for kidney transplant candidates and their support networks
This study is testing a virtual coaching program to help people with end-stage kidney disease and their families understand and navigate the kidney transplant process, especially for those from underserved communities, so they can get the support they need to improve their chances of receiving a transplant.
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Using hyperbaric oxygen to treat severe brain injuries
This study is looking at how breathing in extra oxygen can help people with severe brain injuries feel better and recover, and it’s designed for those who have experienced a serious traumatic brain injury.
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Helping kidney transplant candidates make informed decisions about organ offers
This study is all about helping people waiting for kidney transplants feel more confident and informed when deciding about organ offers, by bringing together patients, their families, and doctors to talk things through and make the process less stressful.
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Understanding kidney transplant benefits for cancer survivors
This study is looking at how kidney transplants can help patients with end-stage kidney disease who have had cancer, and it aims to create a helpful tool for doctors to decide if a transplant or staying on dialysis is better for these patients.
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Creating a wellness research agenda for healthcare workers
This study is bringing together healthcare workers and experts to talk about how to make their work environments better, so they can feel healthier and happier on the job.
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How aging affects vaccine responses in people living with HIV
This study is looking at how age and ongoing inflammation affect how well vaccines work for older adults with HIV, so we can better understand their unique challenges when getting vaccinated.
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Understanding heart failure in people with HIV in South Africa
This study is looking at how living with HIV affects heart health, especially for people in South Africa who have heart failure with preserved ejection fraction, to better understand their unique health challenges and improve care for them.
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Testing the effectiveness of providing nicotine replacement therapy in dental offices.
This study is looking at whether giving out free nicotine replacement therapy samples at dental offices can help smokers quit, making it easier for them to try to stop smoking with some guidance along the way.
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Exploring how Kenyan women adhere to STI and HIV prevention methods
This study is looking at what helps or hinders Kenyan women from sticking to STI and HIV prevention methods, like using a medication called doxycycline, to make sure they have better options for staying healthy.
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Comparing the effects of smoking and non-smoking tobacco products on addiction
This study is looking at how different types of tobacco products, like regular cigarettes and e-cigarettes, affect addiction, using animal models to understand why traditional cigarettes might be more addictive, with the goal of helping to create safer tobacco options for everyone.
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Using blood-based markers to understand cognitive decline in diabetes patients
This study is looking at how diabetes might affect brain insulin signaling and memory in older adults, using tiny particles from blood to help find early signs of cognitive decline and ways to prevent it.
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Evaluating the role of β-nicotyrine in e-cigarette addiction
This study is looking at how a substance called β-nicotyrine, found in e-cigarettes, might affect nicotine addiction, helping us understand the risks of using e-cigarettes better for everyone.
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Improving diabetes care for Spanish-speaking homeless individuals
This study is looking to improve a program that helps Spanish-speaking people who are homeless and have diabetes by offering them support and coaching for 12 weeks to better manage their medications and health.
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Using low-dose aspirin to improve health in older adults
This study is looking at whether taking a low dose of aspirin every day can help older adults, especially those 70 and up, live healthier and longer by potentially preventing heart problems and dementia.
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Identifying blood biomarkers for Alzheimer's disease risk based on sex differences
This study is looking at how different factors for men and women might affect the chances of developing Alzheimer's and related dementias by checking blood markers, so we can help identify people at higher risk and offer them support before any symptoms appear.
Quick answers
How many clinical trials run by Hennepin Healthcare Research Institute are recruiting right now?
10, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 4 countries. The most sites are in United States (9 trials), Canada (1 trial), Nepal (1 trial), Nigeria (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.