Sex-specific blood biomarkers to predict Alzheimer's and related dementias
Official title: Sex-specific risk factors and trajectories of blood biomarkers for Alzheimer's disease and related dementias
Funded at Hennepin Healthcare Research Institute · NIH-11416649 · Data updated 2026-11-12
This project aims to use blood biomarkers to predict risk of Alzheimer's-related conditions in older adults, with attention to how sex differences may change risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hennepin Healthcare Research Institute NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $304,513 |
| NIH project number | 5R01AG079397-03 |
| Project ID | NIH-11416649 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older who are initially dementia-free and live in the community, with consideration of sex-specific risk factors and biomarker profiles.
✕Less likely to help
Individuals without ADRD risk or those not suitable for biomarker-based risk scoring may not benefit from the findings.
What this research studies
This study follows older adults living in the community to see whether blood-based markers of amyloid, tau, and neurodegeneration can forecast who will develop Alzheimer’s disease or related dementias. It emphasizes how risk factors and blood signals may differ between men and women and seeks to create a sex-specific risk score. The research uses longitudinal data to understand how comorbidities influence biomarker interpretation and prognosis. The ultimate goal is to improve personalized prognosis and guide early prevention strategies for ADRD.
Why it matters
Potential benefit: If successful, it could enable earlier identification of individuals at high risk for ADRD and support personalized prevention and monitoring strategies.
How similar studies have gone: Previous work with blood AT(N) biomarkers has shown promise for prognosis, but sex-specific risk scoring in community populations is an area needing further validation.
Where this research is happening
-
Hennepin Healthcare Research Institute
Minneapolis, United States Active
Researchers
- Principal investigator: Murray, Anne M — Hennepin Healthcare Research Institute
- Study coordinator: Murray, Anne M
Related research
Other NIH-funded projects on the same topics.
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P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetic, behavior, and vascular data
Aims to predict Alzheimer’s disease risk in middle-aged South Asians by combining genetic, lifestyle, and vascular information to catch early changes before dementia develops.
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P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data
Aimed at people 21 and older, this project looks at how biology, behavior, and blood vessel health together may signal the early risk of Alzheimer’s disease and related dementias in South Asians.
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Sex-specific blood biomarkers predict dementia risk in older adults
This NIH project tests how blood biomarkers and sex differences predict future dementia in older people, with the goal of personalized prognosis and prevention.
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How sleep and body temperature affect Alzheimer's risk in adults with Down syndrome
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Sleep and body temperature changes linked to Alzheimer’s risk in adults with Down syndrome
This project looks at whether sleep problems and lower body temperature in adults with Down syndrome are linked to higher chances of developing Alzheimer’s disease.
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How blood tests and risk factors differ by sex for Alzheimer's and related dementias
This project looks at blood tests (amyloid, tau, and neurodegeneration markers) and other risk factors in older men and women to help spot who may develop Alzheimer's or related dementias.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.