How aging affects vaccine responses in people living with HIV
Official title: Vaccine immunity and inflammation in the aging person living with HIV
Funded at Hennepin Healthcare Research Institute · NIH-10924495 · Data updated 2026-11-12
This study is looking at how age and ongoing inflammation affect how well vaccines work for older adults with HIV, so we can better understand their unique challenges when getting vaccinated.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hennepin Healthcare Research Institute NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $677,777 |
| NIH project number | 1R01AG084437-01A1 |
| Project ID | NIH-10924495 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals aged 50 and older living with HIV, as well as younger individuals living with HIV and age-matched HIV-negative controls.
✕Less likely to help
Patients who are not living with HIV or those under the age of 21 may not receive direct benefits from this research.
What this research studies
This research investigates how age and chronic inflammation impact vaccine responses in individuals living with HIV. It focuses on older adults who are disproportionately affected by weakened immune responses due to both aging and HIV-related inflammation. The study will involve measuring immune responses to a specific vaccine over time in different age groups, including both HIV-positive and HIV-negative participants. By comparing these responses, the research aims to better understand the challenges faced by older adults living with HIV regarding vaccination.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies for older adults living with HIV, enhancing their immune responses and overall health.
How similar studies have gone: Previous research has shown that chronic inflammation can negatively impact vaccine responses, but this specific focus on aging and HIV is relatively novel.
Where this research is happening
-
Hennepin Healthcare Research Institute
Minneapolis, United States Active
Researchers
- Principal investigator: Frosch, Anne Elizabeth Parker — Hennepin Healthcare Research Institute
- Study coordinator: Frosch, Anne Elizabeth Parker
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.