Identifying blood biomarkers for Alzheimer's disease risk based on sex differences
Official title: Sex-specific risk factors and trajectories of blood biomarkers for Alzheimer's disease and related dementias
Funded at Hennepin Healthcare Research Institute · NIH-10525327 · Data updated 2026-11-12
This study is looking at how different factors for men and women might affect the chances of developing Alzheimer's and related dementias by checking blood markers, so we can help identify people at higher risk and offer them support before any symptoms appear.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hennepin Healthcare Research Institute NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $4,159,504 |
| NIH project number | 1RF1AG079397-01 |
| Project ID | NIH-10525327 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those without a current diagnosis of dementia, who may be at risk due to genetic or other factors.
✕Less likely to help
Patients who are already diagnosed with Alzheimer's disease or related dementias may not benefit from this research.
What this research studies
This research investigates how sex-specific factors influence the risk of developing Alzheimer's disease and related dementias by examining blood biomarkers. The study aims to identify individuals at high risk for these conditions, allowing for timely preventative interventions. By analyzing data from older adults without diagnosed dementia, the research will explore how various characteristics, including comorbidities, affect the interpretation of these biomarkers. The goal is to create a personalized risk score that incorporates these findings to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions of Alzheimer's disease risk and tailored prevention strategies for individuals.
How similar studies have gone: Previous research has shown promise in using blood biomarkers for Alzheimer's disease, but this approach focusing on sex differences is relatively novel.
Where this research is happening
-
Hennepin Healthcare Research Institute
Minneapolis, United States Active
Researchers
- Principal investigator: Murray, Anne M — Hennepin Healthcare Research Institute
- Study coordinator: Murray, Anne M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.