Hyperbaric Oxygen for Brain Injury
Hyperbaric Oxygen Brain Injury Treatment (HOBIT) Trial
['FUNDING_U01'] · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · NIH-11144113
This research explores if giving extra oxygen in a special chamber can help people recover better after a severe brain injury.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HENNEPIN HEALTHCARE RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11144113 on ClinicalTrials.gov |
What this research studies
Severe brain injuries often lead to serious problems and even death, and current treatments haven't shown great success in large studies. This project looks at a treatment called hyperbaric oxygen, where you breathe pure oxygen in a pressurized room. The idea is that this extra oxygen can help heal the brain by improving blood flow, reducing swelling, and promoting new cell growth. This specific effort aims to figure out the best way to give this treatment to prepare for a larger study, by identifying optimal pressure and whether additional oxygen after treatment helps.
Who could benefit from this research
Good fit: Ideal candidates would be individuals who have recently experienced a severe traumatic brain injury.
Not a fit: Patients with mild brain injuries or those whose injuries occurred a long time ago may not benefit from this acute treatment.
Why it matters
Potential benefit: If successful, this approach could lead to a new and effective treatment to improve recovery and reduce long-term problems for people with severe traumatic brain injury.
How similar studies have performed: Preclinical and early phase II clinical investigations have shown promising results, suggesting that hyperbaric oxygen may improve brain metabolism and neurological outcomes.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- HENNEPIN HEALTHCARE RESEARCH INSTITUTE — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROCKSWOLD, GAYLAN L — HENNEPIN HEALTHCARE RESEARCH INSTITUTE
- Study coordinator: ROCKSWOLD, GAYLAN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury