Understanding heart failure in people with HIV in South Africa
Official title: Clinical and immunologic factors underlying heart failure with preserved ejection fraction among persons with HIV in South Africa
Funded at Hennepin Healthcare Research Institute · NIH-10915005 · Data updated 2026-11-12
This study is looking at how living with HIV affects heart health, especially for people in South Africa who have heart failure with preserved ejection fraction, to better understand their unique health challenges and improve care for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hennepin Healthcare Research Institute NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 15, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $513,760 |
| NIH project number | 5R01HL160437-04 |
| Project ID | NIH-10915005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV in South Africa, particularly those experiencing or at risk for heart failure.
✕Less likely to help
Patients who are not living with HIV or those who do not reside in South Africa may not benefit from this research.
What this research studies
This research investigates the clinical and immunologic factors that contribute to heart failure with preserved ejection fraction (HFpEF) among individuals living with HIV in South Africa. It aims to identify how chronic HIV disease affects heart health, particularly focusing on the unique risk factors present in this population. By examining the relationship between HIV and heart failure, the study seeks to characterize different clinical profiles based on co-existing health conditions. This approach will help in understanding the specific challenges faced by patients in low-to-middle income countries.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for heart failure in people living with HIV.
How similar studies have gone: While research has focused on ischemic heart disease in HIV patients, this specific investigation into HFpEF in a South African context is relatively novel.
Where this research is happening
-
Hennepin Healthcare Research Institute
Minneapolis, United States Active
Researchers
- Principal investigator: Baker, Jason V — Hennepin Healthcare Research Institute
- Study coordinator: Baker, Jason V
Related research
Other NIH-funded projects on the same topics.
-
AI-supported heart failure diagnosis and management in Rwanda
Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
-
AI-assisted heart failure diagnosis in Rwanda using focused ultrasound
An NIH-funded project will test whether AI-enhanced, easy-to-use heart ultrasound can help non-experts diagnose and manage heart failure in Rwanda.
-
HF endotypes in heart failure using ethical multi-modal AI and molecular data
A patient-friendly project that uses advanced AI and multiple kinds of health data to identify distinct heart failure subtypes that could guide personalized care.
-
Triple gene therapy approach to heal the heart after a heart attack
A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.
-
Digital-first heart failure care delivery in Uganda
A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.
-
Digital-first heart failure care delivery in Uganda
A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.