Understanding kidney transplant benefits for cancer survivors
Official title: A clinical decision support tool to understand the survival benefit of kidney transplantation in candidates with a history of cancer
Funded at Hennepin Healthcare Research Institute · NIH-10944113 · Data updated 2026-11-12
This study is looking at how kidney transplants can help patients with end-stage kidney disease who have had cancer, and it aims to create a helpful tool for doctors to decide if a transplant or staying on dialysis is better for these patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hennepin Healthcare Research Institute NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 5, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $348,657 |
| NIH project number | 1R01DK140270-01 |
| Project ID | NIH-10944113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with end-stage kidney disease who have a history of cancer and are currently in remission.
✕Less likely to help
Patients with active cancer or those who are not candidates for kidney transplantation due to other health issues may not benefit from this research.
What this research studies
This research investigates how kidney transplantation can benefit patients with end-stage kidney disease (ESKD) who have a history of cancer. It aims to develop a clinical decision support tool that helps nephrologists evaluate the survival benefits of transplantation versus remaining on dialysis for these patients. By analyzing data on cancer remission and kidney function, the research seeks to provide clearer guidelines for when patients with a history of cancer should be considered for transplantation. This tool will help improve decision-making for both patients and healthcare providers.
Why it matters
Potential benefit: If successful, this research could lead to more informed decisions about kidney transplantation for cancer survivors, potentially improving their survival rates.
How similar studies have gone: While there is limited data on this specific approach, similar research has shown promise in improving outcomes for patients with complex health histories.
Where this research is happening
-
Hennepin Healthcare Research Institute
Minneapolis, United States Active
Researchers
- Principal investigator: Hart, Allyson — Hennepin Healthcare Research Institute
- Study coordinator: Hart, Allyson
Related research
Other NIH-funded projects on the same topics.
-
Strategies for HIV-to-HIV kidney transplants to increase organ donations
This project looks at making HIV-to-HIV kidney transplantation more common to help people with HIV get transplants faster by boosting organ donation and changing practice.
-
Biomarker-guided Immunosuppression in Kidney Transplant Patients
A multicenter study in kidney transplant recipients is testing whether a biomarker score from HLA-DR/DQ can guide changes in immunosuppression to reduce rejection risk and drug toxicity.
-
Helping the immune system accept a donated kidney in patients without prior sensitization
This project will try giving specially treated donor B cells alongside immune-sparing medicines to teach the immune systems of kidney transplant patients without prior antibodies to accept the new kidney.
-
Lowering donor-specific antibodies in sensitized kidney transplant patients
This project works to reduce harmful donor-specific antibodies in people who are sensitized and need a kidney transplant so their new organ lasts longer.
-
Reducing geographic disparities in kidney transplant access with AI and operations research
Aiming to use AI and operations research to make kidney transplant access more fair across different regions in the U.S.
-
Centralized patient coaching to boost live donor kidney transplantation
A US-wide program trains patients, caregivers, and their networks with coaching to help them pursue living donor kidney transplantation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.