Using hyperbaric oxygen to treat severe brain injuries
Official title: Hyperbaric Oxygen Brain Injury Treatment (HOBIT) Trial - CCC
Funded at Hennepin Healthcare Research Institute · NIH-11005150 · Data updated 2026-11-12
This study is looking at how breathing in extra oxygen can help people with severe brain injuries feel better and recover, and it’s designed for those who have experienced a serious traumatic brain injury.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hennepin Healthcare Research Institute NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | January 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $626,120 |
| NIH project number | 3U01NS095926-05S1 |
| Project ID | NIH-11005150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced severe traumatic brain injuries.
✕Less likely to help
Patients with mild brain injuries or those who do not have access to hyperbaric oxygen therapy may not benefit from this research.
What this research studies
This research investigates the effects of hyperbaric oxygen therapy on patients with severe traumatic brain injury (TBI). The approach involves administering increased oxygen levels to the brain to counteract cellular energy failure and reduce brain cell death. The study aims to optimize treatment parameters, such as pressure and frequency, to maximize benefits while minimizing risks of oxygen toxicity. By gathering critical data, this trial will help inform a larger phase III study on the efficacy of hyperbaric oxygen therapy for TBI patients.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery outcomes for patients suffering from severe traumatic brain injuries.
How similar studies have gone: Previous studies have shown promising results for hyperbaric oxygen therapy in improving outcomes for brain injury patients, indicating potential for success in this approach.
Where this research is happening
-
Hennepin Healthcare Research Institute
Minneapolis, United States Active
Researchers
- Principal investigator: Rockswold, Gaylan L — Hennepin Healthcare Research Institute
- Study coordinator: Rockswold, Gaylan L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.