Tracking vaccine responses in older adults living with HIV

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines how age and HIV status affect immune responses to the conjugate pneumococcal vaccine over time. It focuses on individuals aged 50 and older living with HIV, as well as younger individuals with and without HIV, to understand the impact of chronic inflammation on vaccine efficacy. Participants will be monitored for both short-term and long-term immune responses following vaccination, allowing researchers to assess the durability of vaccine protection in this population. The study aims to fill gaps in existing research by including older adults who are often underrepresented in vaccine studies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age\>=18 years
* HIV Diagnosis
* On Antiretroviral Therapy with HIV Viral Load\<200 within last year

Exclusion Criteria:

* Other significant immunosuppressing condition
* Age\< 18 years
* Pregnancy (at enrollment)
* Contraindication to pneumococcal vaccination
* Known contraindication to non-clinical blood draws (severe anemia last hemoglobin \<8g/dl)
* Subjects who, in the opinion of the Investigator, may be non-adherent to study schedules or procedures.
* Adults unable to consent
* Individuals with impaired ability to consent
* Incarceration at time of enrollment

Controls inclusion criteria:

* Age\>=18 years
* HIV Ag-Ab test negative

Where it's running

• Hennepin Healthcare System
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Study coordinator: Anne Frosch, MD
• Email: Anne.Frosch@hcmed.org
• Phone: (612)-283-4349

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.