Vaccine responses in older people living with HIV
Official title: Vaccine immunity and inflammation in the aging person living with HIV
Funded at Hennepin Healthcare Research Institute · NIH-11390461 · Data updated 2026-11-12
This project looks at how age and HIV infection affect how well a pneumococcal vaccine works, especially in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hennepin Healthcare Research Institute NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $667,915 |
| NIH project number | 5R01AG084437-03 |
| Project ID | NIH-11390461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HIV aged 50 and older, and age-matched HIV-uninfected controls, including both younger and older cohorts.
✕Less likely to help
Healthy adults without HIV or those not receiving the pneumococcal vaccine may not directly benefit.
What this research studies
Older adults living with HIV often have ongoing inflammation that could weaken vaccine responses. The study will follow a diverse group of participants to compare immune responses to the PCV20 vaccine across age groups and HIV status, tracking antibodies, B cells, and CD4 T cells over two years. By analyzing how age and chronic inflammation interact with HIV, researchers aim to understand why vaccines may be less effective in this population and what could improve protection.
Why it matters
Potential benefit: If successful, findings could guide better vaccination strategies and timing for older people with HIV to improve protection against pneumococcal disease.
How similar studies have gone: Previous work shows age and immune status affect vaccine responses, but this study directly compares age and HIV status with long-term follow-up.
Where this research is happening
-
Hennepin Healthcare Research Institute
Minneapolis, United States Active
Researchers
- Principal investigator: Frosch, Anne Elizabeth Parker — Hennepin Healthcare Research Institute
- Study coordinator: Frosch, Anne Elizabeth Parker
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.