Investigating blood biomarkers and risk factors for Alzheimer's disease in men and women
Official title: Sex-specific risk factors and trajectories of blood biomarkers for Alzheimer's disease and related dementias
Funded at Hennepin Healthcare Research Institute · NIH-11063450 · Data updated 2026-11-12
This study is looking at how different factors for men and women might affect the chances of developing Alzheimer's and related memory issues, using blood tests to spot those at higher risk before they show any symptoms, so we can help with early diagnosis and prevention.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hennepin Healthcare Research Institute NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $387,497 |
| NIH project number | 3RF1AG079397-01S1 |
| Project ID | NIH-11063450 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults living in the community who are currently healthy and have no diagnosed dementia.
✕Less likely to help
Patients who are already diagnosed with Alzheimer's disease or related dementias may not benefit from this research.
What this research studies
This research focuses on understanding how sex-specific factors influence the risk of developing Alzheimer's disease and related dementias (ADRD). By examining blood biomarkers associated with these conditions, the study aims to identify individuals at high risk before symptoms appear. The approach includes analyzing data from older adults in the community, considering various health factors and how they differ between men and women. The goal is to create a personalized risk score that can help in early diagnosis and prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and personalized prevention strategies for Alzheimer's disease and related dementias.
How similar studies have gone: While there has been research on Alzheimer's risk factors, this study's focus on sex-specific biomarkers and community-based longitudinal analysis is relatively novel.
Where this research is happening
-
Hennepin Healthcare Research Institute
Minneapolis, United States Active
Researchers
- Principal investigator: Murray, Anne M — Hennepin Healthcare Research Institute
- Study coordinator: Murray, Anne M
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P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data
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Sex-specific blood biomarkers predict dementia risk in older adults
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Sleep and body temperature changes linked to Alzheimer’s risk in adults with Down syndrome
This project looks at whether sleep problems and lower body temperature in adults with Down syndrome are linked to higher chances of developing Alzheimer’s disease.
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Sex-specific blood biomarkers to predict Alzheimer's and related dementias
This project aims to use blood biomarkers to predict risk of Alzheimer's-related conditions in older adults, with attention to how sex differences may change risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.