Condition

Weight Gain clinical trials and research

• 18Clinical trials
• 36NIH research projects
• 17Countries

Newest Weight Gain clinical trials

All recruiting trials (18)

• Pregnant women weight-management support via an app and care model

  Aims to try a smartphone-based weight-management program plus professional support for pregnant women to see if it helps manage gestational weight and promote healthy behaviors.

  Recruiting Mackay Medical College · Taipei · NCT07814885

• Semaglutide microdosing for weight control in people living with HIV

  Small weekly doses of semaglutide will be tried to see if they prevent weight regain in adults living with HIV after an initial weight-loss induction.

  Recruiting Phase 2 The University of Texas Health Science Center, Houston · Houston, Texas · NCT07325500

• Time-restricted eating to help keep weight off

  This 12-month randomized test will see if eating only within a 10-hour daily window helps adults who recently lost weight keep it off and limit fat regain.

  Recruiting NYU Langone Health · New York, New York · NCT07190170

• Digital support for pregnant women with a BMI of 25 or higher

  This study is testing a digital care guide to see if it can help pregnant women with a higher BMI manage their weight and improve their mental health during pregnancy.

  Recruiting at 2 sites Center for Clinical Research and Prevention · Hillerød and 1 other locations · NCT06734910

• High-intensity interval exercise to support brain activity and weight maintenance

  This trial will test whether a 12-week high-intensity interval training (HIIT) program changes brain activity and helps with weight maintenance in adults 18–70, including people who regained weight after bariatric surgery.

  Recruiting Joslin Diabetes Center · Boston, Massachusetts · NCT06511310

• Evaluating tirzepatide for treating obesity in adolescents

  This study is testing if tirzepatide can help teenagers with obesity lose weight and improve their heart health while they follow a healthy eating and exercise program.

  Recruiting Phase 3 Eli Lilly and Company · Los Angeles, California and 68 other locations · NCT06439277

• Comparing two methods for weight loss after gastric bypass

  This study is testing two different ways to help people who have gained weight after gastric bypass surgery lose weight again, to see which method works better and is safer.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06131281

• Obesity prevention program for high-risk infants

  This study is testing a parenting program to help prevent obesity in infants from low-income or minority communities during regular doctor visits.

  Recruiting Phase 2 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT06028113

• Weight changes in male prisoners in Martinique

  This study looks at how the weight of male prisoners in Martinique changes from when they arrive to three months later and what factors like exercise, diet, and mental health might affect those changes.

  Recruiting University Hospital Center of Martinique · Ducos · NCT05982132

• Treating insomnia to improve weight loss in breast cancer survivors

  This study is testing whether a sleep therapy can help overweight or obese breast cancer survivors lose weight more effectively.

  Recruiting at 4 sites Johns Hopkins University · Washington D.C., District of Columbia and 3 other locations · NCT05780814

• Understanding how sleep affects metabolism and weight gain

  This study is testing how not getting enough sleep and the timing of sleep can affect metabolism and weight gain in people.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT05775627

• Effects of Dolutegravir and Tenofovir Alafenamide on Metabolism in Healthy Volunteers

  This study is testing how two HIV medications, dolutegravir and tenofovir alafenamide, affect metabolism and weight in healthy adults aged 18 to 55.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05652478

• Grocery delivery to support healthy weight gain in low-income pregnant young women

  This study is testing if grocery delivery of healthy foods can help low-income pregnant young women in Michigan gain weight safely and improve their diets.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05000645

• Comparing two types of distal gastric bypass for patients with weight regain after gastric bypass surgery

  This study is testing two different types of gastric bypass surgery to see which one helps people who have regained weight after their first surgery lose weight more effectively.

  Recruiting at 6 sites St. Antonius Hospital · Arnhem, Gelderland and 7 other locations · NCT04894838

• Effects of exercise on fat tissue in obese individuals

  This study tests how exercise affects fat tissue in people with obesity to see if it can help improve their metabolism and manage weight better.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT04812314

• Feeding preterm infants different formulas with varying beta-palmitate levels

  This study tests if feeding preterm infants different formulas with high or low levels of a fat called beta-palmitate helps them gain weight better than those who are fed their mother's milk.

  Recruiting Ospedali Riuniti Ancona · Ancona and 1 other locations · NCT04541095

• Impact of Kangaroo Care on Weight Gain in Preterm Infants

  This study is testing if holding preterm infants skin-to-skin during their first feeding helps them gain weight better than if they are held during their second feeding.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Istanbul · NCT04252547

• Effects of menopause and aging on weight gain and fat distribution

  This study is testing how menopause affects weight gain and belly fat in women by looking at hormones and seeing if adjusting these hormones can help reduce fat.

  Recruiting Phase 4 University of Colorado, Denver · Aurora, Colorado · NCT04043520

NIH-funded research (36)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Game-based mobile app to help pregnant women with overweight/obesity manage weight in Nepal

  A new app designed for pregnant women in Nepal with overweight or obesity to help manage weight gain during pregnancy and reduce weight retention after birth.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11601016

• How the brain’s support structure around certain neurons may affect appetite and weight in Alzheimer’s-related conditions

  A new NIH grant explores whether a brain “support network” around specific neurons in a region linked to appetite could influence weight gain in people affected by Alzheimer’s disease and related dementia.

  NIH research University of South Florida · Tampa, United States · NIH-11430870

• Center-based childcare to curb excess weight gain in preschoolers from low-income families during summer

  A summer program using center-based childcare to help preschoolers from low-income households gain and maintain healthier weights.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11416685

• Game-based mobile app to help pregnant women with overweight/obesity in Nepal manage weight

  A mobile app designed for pregnant women in Nepal who start pregnancy overweight or obese to help them manage weight gain and reduce postpartum weight retention.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11416297

• Preventing weight gain in Air Force personnel with a new mobile health program

  A mobile health program is being tested to help young Air Force members 18+ avoid gaining weight.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11393314

• Preventing weight gain and blood sugar problems after kidney transplant

  This project offers a diet and activity program for people who have had a kidney transplant to help prevent weight gain and problems with blood sugar.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11374419

• What’s UP with Summer: Understanding Why Weight Grows Faster in Summer for Teens and Kids

  A large study follows kids and adolescents to see why their weight tends to rise more during summer months than during the school year, with a focus on those from lower-income families.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11359582

• How our brain signals and appetite relate to obesity risk in teens

  A study in teenagers looks at how the brain’s response to food at fullness might predict who will gain weight in the future.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11332416

• A short sleep program in pediatric primary care to help prevent excess weight gain

  This offers a brief sleep-improvement program for school-aged children seen at routine pediatric visits to help prevent unhealthy weight gain.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11322642

• Why preschoolers from low-income families gain weight faster over the summer

  This project looks at what causes faster summer weight gain in preschool children from low-income families and where they spend their time.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11295468

• Digital program to help pregnant people keep weight gain on track

  A remote, personalized digital program uses automated rules to help pregnant people with overweight or obesity keep weight gain within healthy ranges.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11290317

• Understanding Why Adolescents Gain More Weight in Summer Than During the School Year

  This project looks at why children and adolescents tend to gain more weight during summer vacation compared to the school year, especially those from lower-income families.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11123230

• A mobile app to help teens manage eating habits and prevent weight gain

  This project is creating a new mobile app to help teenagers who struggle with overeating and weight gain.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11121832

• Mobile phone program to help Air Force members prevent unhealthy weight gain

  It uses a phone-based program to help U.S. Air Force members keep their weight stable and protect fitness for duty.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11121821

• Using exenatide with nicotine patches to help people quit smoking and manage weight gain.

  This study is looking at how well using exenatide, a medication that helps with appetite and blood sugar, along with nicotine patches can help people quit smoking while also managing weight gain that often happens after quitting.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11101271

• How brain signals related to fullness affect obesity risk in adolescents

  This study is looking at how differences in brain signals that tell us when we're full might affect the chances of gaining weight in teenagers, especially those with a family history of obesity, by using brain scans and tracking their eating habits over time.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11089502

• Understanding why preschoolers from low-income families gain weight during the summer.

  This study is looking at why young kids from low-income families tend to gain weight faster during the summer when they're not in daycare, and it aims to find ways to help them stay active and eat healthier during that time.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11075900

• Using grocery delivery to help low-income pregnant young women gain healthy weight

  This study is looking at how grocery delivery services can help low-income pregnant young women choose healthier foods during their pregnancy, making it easier for them to get nutritious options and improve their health and their baby's health.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11074659

• Exploring how food insecurity affects weight gain during and after pregnancy

  This study is looking at how not having enough food can affect weight gain during pregnancy and after having a baby, focusing on how feelings and social situations play a role in what women eat; it's designed for women who might be facing these challenges and aims to find better ways to support their health.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11065496

• Improving sleep to prevent obesity in children

  This study is looking at a short program to help kids get better sleep so they can maintain a healthy weight, especially for those who might be at higher risk due to their background.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11056832

• How HIV integrase drugs affect weight and heart health differently by sex

  This work looks at why people with HIV—especially women—often gain weight on integrase-based HIV medicines and how that weight gain may harm heart and metabolic health.

  NIH research Emory University · Atlanta, United States · NIH-11046593

• Using a digital platform to help pregnant women manage weight gain

  This study is testing a helpful online program called the Healthy Mom Zone, which is designed for pregnant women who are overweight or obese, to support them in managing their weight gain during pregnancy for better health for both mom and baby.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11014352

• Identifying genetic factors that cause weight gain from antipsychotic medications

  This study is looking at how your genes might affect weight gain from antipsychotic medications, which can lead to health issues like diabetes and heart disease, and it's for both kids and adults to help find better ways to manage these risks.

  NIH research Washington University · Saint Louis, United States · NIH-11003663

• Identifying urine metabolites that predict weight gain during pregnancy in South African women with HIV

  This study is looking at how certain substances in urine can help predict if women with HIV might gain too much weight during and after pregnancy, so we can find ways to support their health and prevent future issues like diabetes and heart problems.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11000408

• Investigating how food insecurity affects weight gain in adolescents from low to moderate income households

  This study is looking at how not having enough food can lead to weight gain in teenagers from families with limited money, and it wants to find out what habits might cause them to eat more unhealthy foods so that we can create better ways to help prevent obesity.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11000281

• How genetic factors related to GLP-1 affect appetite and weight gain in children

  This study is looking at how certain genes related to a hormone that helps control hunger might affect how kids aged 9-12 eat and respond to food, to better understand their risk of gaining weight.

  NIH research Dartmouth College · Hanover, United States · NIH-10997768

• Creating a mobile app to help teens manage eating habits and prevent weight gain

  This study is testing a new mobile app that helps teens who have trouble with overeating by using fun and easy-to-follow strategies, making it easier for them to develop healthier eating habits and feel more in control.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10911930

• Understanding why adolescents gain weight more during summer than school

  This study is looking at why kids tend to gain weight faster during the summer than when they're in school, and it’s for families with children who want to understand how things like exercise, sleep, screen time, and eating habits affect their health over the years.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-10908400

• Investigating weight gain and its health effects in people with HIV on specific treatment in Haiti.

  This study is looking at how gaining weight affects the health of people living with HIV in Haiti who are on a specific treatment, focusing on things like blood sugar, blood pressure, and cholesterol, to help find better ways to support their health.

  NIH research Gheskio Center · Port-Au-Prince, Haiti · NIH-10884392

• A program to help pregnant women manage weight gain and prevent obesity.

  This study is testing a friendly health coaching program for pregnant and new moms to help them manage their weight during and after pregnancy, using phone calls and online tools, to see if it works better than regular care in clinics that support different communities.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10809624

• How sleep patterns and gut bacteria in infants affect rapid weight gain

  This study is looking at how babies' sleep habits and gut bacteria affect their weight gain in the first six months, with the goal of finding ways to help prevent obesity and keep kids healthy as they grow.

  NIH research Arizona State University-Tempe Campus · Tempe, United States · NIH-10770407

• Preventing obesity in children by managing weight gain during pregnancy

  This study is looking at how helping women with severe obesity manage their weight during pregnancy can lead to healthier outcomes for their children, and it aims to find the best weight gain goals for these moms to support both their health and their kids' future well-being.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10754886

• Investigating how brain inflammation affects weight gain during pregnancy

  This study is looking at how inflammation in a part of the brain affects weight gain during pregnancy, helping us understand why some women gain more weight than others and how to better manage it for healthier pregnancies.

  NIH research Emory University · Atlanta, United States · NIH-10742432

• Using mobile health tools to help overweight and obese women manage weight gain during pregnancy

  This study is looking at how using mobile health tools can help pregnant women who are overweight or obese manage their weight gain in a way that fits their needs, so both they and their babies can be healthier.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-10599159

• Helping low-income mothers manage weight gain during pregnancy

  This study is looking to help low-income moms manage their weight during pregnancy by providing easy-to-use online support and resources, especially through community programs like WIC, to ensure both they and their babies stay healthy.

  NIH research Lsu Pennington Biomedical Research Ctr · Baton Rouge, United States · NIH-10532765

• Encouraging families to be more active together using a mobile app

  This study is all about helping families get active together to keep kids and teens at a healthy weight, and it involves testing a fun mobile app that tracks your family's activities and connects with devices like Fitbit, while also providing tips and support for parents.

  NIH research University of Florida · Gainesville, United States · NIH-10459232

Related topics

Quick answers

How many Weight Gain clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (12 trials), Taiwan (2 trials), Turkey (Türkiye) (1 trial), Denmark (1 trial), Martinique (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 4: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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